| 微波技术在药物中间体合成中的应用 |
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| 引用本文： | 邓兰,徐鸣夏,郑时龙. 微波技术在药物中间体合成中的应用[J]. 中国现代应用药学, 2001, 18(6): 455-456 |
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| 作者姓名： | 邓兰 徐鸣夏 郑时龙 |
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| 作者单位： | 四川大学华西药学院,成都,610041 |
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| 摘 要： | 目的运用微波技术进行药物中间体合成.方法对硝基还原反应、缩合反应、环合反应采用微波催化的方法进行.结果合成五个药物中间体,反应时间均大大缩短.结论该方法具有操作简单,反应时间短等优点,有一定实用意义.
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| 关 键 词： | 微波辐射 还原反应 缩合反应 环合反应 |
| 修稿时间： | 2000-07-11 |
Study on application of microwave irradiation in intermediate for drug synthetic reactions |
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| Deng Lan (Deng L,Xu ming xia (Xu Mx,Zheng shi long (Zheng SL. Study on application of microwave irradiation in intermediate for drug synthetic reactions[J]. The Chinese Journal of Modern Applied Pharmacy, 2001, 18(6): 455-456 |
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| Authors: | Deng Lan (Deng L Xu ming xia (Xu Mx Zheng shi long (Zheng SL |
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| Abstract: | OBJECTIVE: To synthesize the intermediates for drugs by microwave irradiation. METHOD: Reduction reaction, condensation reaction and cyclization reaction were studied by microwave irradiation. RESULTS: Five intermediates were synthesized and time was shortened greatly. CONCLUION: The method was simple and facile, which appears to be practical. |
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| Keywords: | Microwave irradiation Reduction reaction Condensation reaction Cyclization reaction |
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