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| 实验性自身免疫性脑脊髓炎中枢神经系统浸润细胞凋亡的研究 | |
| 引用本文： | 吕佩源,陈慧芳,陈竞清,翟金萍,林嘉友. 实验性自身免疫性脑脊髓炎中枢神经系统浸润细胞凋亡的研究[J]. 中国神经免疫学和神经病学杂志, 2004, 11(5): 277-279 |
| 作者姓名： | 吕佩源 陈慧芳 陈竞清 翟金萍 林嘉友 |
| 作者单位： | 1. 河北省人民医院神经内科,河北,石家庄,050051 2. 河北医科大学附属第三医院骨科,河北,石家庄,050053 3. 河北省人民医院病理科,河北,石家庄,050051 4. 中国医学科学院,中国协和医科大学,基础医学研究所免疫学室,北京,100005 |
| 基金项目： | 河北省卫生厅基金资助项目 (0 10 5 4) |
| 摘 要： | 目的 探讨实验性自身免疫性脑脊髓炎 ( EAE)中枢神经系统 ( CNS)中浸润细胞的凋亡情况。方法 用脱氧核糖核苷酸末端转移酶介导的缺口末端标记 ( TUNEL)技术动态检测 EAE病程不同阶段大鼠 CNS中浸润细胞的凋亡变化。结果 TUNEL阳性细胞的数量随病情进展呈单峰曲线 ,形态学观察支持 TUNEL阳性细胞主要为淋巴细胞、巨噬细胞和小胶质细胞。结论 细胞凋亡是 EAE动物 CNS中浸润细胞的重要清除方式。 |
| 关 键 词： | 实验性自身免疫性脑脊髓炎 中枢神经系统 细胞凋亡 TUNEL |
| 文章编号： | 1006-2963(2004)05-0277-03 |
| 修稿时间： | 2003-12-24 |
Study on Apoptosis in Central Nervous System of Experimental Autoimmune Encephalomyelitis |
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| LU Pei yuan ,CHEN Hui fang ,CHEN Jing qing ,ZHAI Jin ping ,LIN Jia you. Study on Apoptosis in Central Nervous System of Experimental Autoimmune Encephalomyelitis[J]. Chinese Journal of Neuroimmunology and Neurology, 2004, 11(5): 277-279 | |
| Authors: | LU Pei yuan CHEN Hui fang CHEN Jing qing ZHAI Jin ping LIN Jia you |
| Affiliation: | LU Pei yuan 1,CHEN Hui fang 1,CHEN Jing qing 2,ZHAI Jin ping 3,LIN Jia you 4 |
| Abstract: | Objective To study the apoptotic cells in central nervous system (CNS) with experimental autoimmune encephalomyelitis (EAE) at various stages of the course. Methods TdT mediated dUTP nick end labeling (TUNEL) was performed in samples of spinal cord with EAE. Results The number of TUNEL positive cells has significantly course related character in EAE,and the majority of TUNEL positive cells were T cells,macrophages and microglia. Conclusions It is suggested that apoptosis may be a major clearance process of infiltrated cells in the CNS of EAE. |
| Keywords: | experimental autoimmune encephalomyelitis central nervous system apoptosis TUNEL |
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