肝硬化患者胆囊运动功能与Child-Pugh分级的相关性研究

探讨肝硬化患者胆囊运动功能与Child-Pugh分级之间的关系。研究对象分为正常对照组14例和肝硬化组62例,并行Child—Pugh分级。全部受试者均行mTc—EHIDA肝胆动态显像得到:①潜伏期(LP);②排胆期(EP);计算③排胆分数(GBEF);④排胆率(ER)。比较正常对照组与肝硬化组GBEF、LP、ER,可见肝硬化患者GBEF和ER明显低于正常对照组(P<0．01),LP高于正常对照组(P<0．05)。Child-Pugh A级、B级、C级三组的胆石发生率和胆囊运动异常发生率分别为:7．7％和15．4％,19．0％和19．0％,35．7%和46．4％。Child-Pugh分级越高,胆囊运动异常发生率越高(P<0．05),胆结石发生率也越高(但P>0．05),同时胆囊壁厚度越厚(P<0．05)。肝硬化患者的胆囊运动功能减弱,且与肝功能损害程度有一定的关系。

Gallbladder motility in patients with liver cirrhosis and Child - Pugh grade

To investigate the relationship between gallbladder motility function and Child - Pugh grade. The study included 14 normal subjects and 62 patients with liver cirrhosis. Every patient had their own Child - Pugh grade. All subjects received 99mTc - EHIDA hepatobiliary scintigraphy. Latent period ( LP) , ejection period (EP) , gallbladder ejection fraction ( GBEF) and ejection rate (ER) were acquired. GBEF and ER of liver cirrhosis patients are lower than that of normal subjects. LP of liver cirrhosis patients is higher than that of normal subjects and there were significant difference in GBEF, ER and LP. Significant difference is found in incidence rate of gallbladder motility disfunction in different Child - Pugh grade. There was no significant difference in incidence rate of gallstones in different Child - pugh grade. The gallbladder motility function of cirrhosis patients is impaired and is related to the Child - Pugh grade.