Role of acetaldehyde in ethanol-induced conditioned taste aversion in rats |
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Authors: | M?Dolores?Escarabajal Philippe?De?Witte Email author" target="_blank">Etienne?QuertemontEmail author |
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Institution: | (1) área de Psicobiología, Universidad de Jaén, 23071, Jaén, Spain,;(2) Biologie du Comportement, Université catholique de Louvain, Place Croix du Sud 1, 1348, Louvain-la-Neuve, Belgium,;(3) Laboratoire de Psychopharmacologie, Université de Liège, Boulevard du Rectorat 5/B32, 4000, Liège, Belgium, |
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Abstract: | Rationale. In spite of many recent studies on the effects of acetaldehyde, it is still unclear whether acetaldehyde mediates the reinforcing
and/or aversive effects of ethanol.
Objectives. The present study reexamined the role of acetaldehyde in ethanol-induced conditioned taste aversion (CTA). A first experiment
compared ethanol- and acetaldehyde-induced CTA. In a second experiment, cyanamide, an aldehyde dehydrogenase inhibitor, was
administered before conditioning with either ethanol or acetaldehyde to investigate the effects of acetaldehyde accumulation.
Methods. A classic CTA protocol was used to associate the taste of a saccharin solution with either ethanol or acetaldehyde injections.
In experiment 1, saccharin consumption was followed by injections of either ethanol (0, 0.5, 1.0, 1.5 or 2.0 g/kg) or acetaldehyde
(0, 100, 170 or 300 mg/kg). In experiment 2, the rats were pretreated with either saline or cyanamide (25 mg/kg) before conditioning
with either ethanol or acetaldehyde.
Results. Both ethanol and acetaldehyde induced significant CTA. However, ethanol produced a very strong CTA relative to acetaldehyde
that induced only a weak CTA even at toxic doses. Cyanamide pretreatments significantly potentiated ethanol- but not acetaldehyde-induced
CTA.
Conclusions. The present results indicate that ethanol-induced CTA does not result from brain acetaldehyde effects. In contrast, it is
suggested that the reinforcing effects of brain acetaldehyde might actually reduce ethanol-induced CTA. Our results also suggest
that the inhibition of brain catalase activity may contribute to the potentiating effects of cyanamide on ethanol-induced
CTA.
Electronic Publication |
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Keywords: | Ethanol Acetaldehyde Conditioned taste aversion Cyanamide Aldehyde dehydrogenase |
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