| 糖化血红蛋白对抗精神病药治疗时血糖的监测 |
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| 引用本文： | 傅伟忠,瞿正万,陈美娣,古嘉琪,王涛,江琦,王豪,袁杰,杨振东,李亚明,胡承平,曹凤妹,瞿嘉兴.糖化血红蛋白对抗精神病药治疗时血糖的监测[J].临床精神医学杂志,2007,17(1):16-18. |
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| 作者姓名： | 傅伟忠 瞿正万 陈美娣 古嘉琪 王涛 江琦 王豪 袁杰 杨振东 李亚明 胡承平 曹凤妹 瞿嘉兴 |
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| 作者单位： | 200122,上海市浦东新区精神卫生中心 |
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| 基金项目： | 河北省唐山市科技局资助项目 |
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| 摘 要： | 目的:探讨糖化血红蛋白(HbA1C)在抗精神病药治疗中对血糖变化的监测作用.方法:对198例单用氯丙嗪或利培酮治疗的精神分裂症住院患者于治疗前、治疗1、2、3、6、12个月测定HbA1C及血糖浓度并与常规血糖检测指标进行比较.结果:HbA1C浓度随治疗时间延长而增高,与血糖浓度变化呈显著正相关,与血葡萄糖调节受损(IGR)的发生呈平行发展,治疗1年后异常率为11.6%.结论:HbA1C检测稳定性好,结合空腹血糖等常规指标,是抗精神病药治疗中观察血糖变化的有效指标.
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| 关 键 词： | 糖化血红蛋白 抗精神病药 血糖 |
| 文章编号： | 1005-3220（2007）01-0016-03 |
| 收稿时间： | 2006-06-23 |
| 修稿时间： | 2006年6月23日 |
Evaluating the monitor role of glycohemoglobin in the treatment of antipsychotics |
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| FU Wei-zong,QU Zheng-wan,CHEN Mei-di,GU Jia-qi,WANG Tao,JIANG Qi,WANG Hao,YUAN Ji,YANG Zheng-dong,LI Ya-ming,HU Cheng-ping,CAO Feng-mei,QU Jiang-xing.Evaluating the monitor role of glycohemoglobin in the treatment of antipsychotics[J].Journal of Clinical Psychological Medicine,2007,17(1):16-18. |
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| Authors: | FU Wei-zong QU Zheng-wan CHEN Mei-di GU Jia-qi WANG Tao JIANG Qi WANG Hao YUAN Ji YANG Zheng-dong LI Ya-ming HU Cheng-ping CAO Feng-mei QU Jiang-xing |
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| Institution: | Mental Health Centre of Newdistrict of Pudong in Shanghai, Shanghai 200122, China |
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| Abstract: | Objective: To explore the monitor role of glycohemoglobin (HbA1C) in the treatment of antipsychotics. Method:198 inpatients with schizophrenia were divided randomly into chlorpromazine group and risperidone group.HbA1C and fasting plasma glucose were tested before treatment and at 1,2,3,6,12 month after treatment, and compared with clinical routine fasting plasma glucose test. Results:The level of HbA1C trended to increase with the time of hospitalization and associated with the level of fasting plasma glucose and the incidence of imparied glucose regulation (IGR),whose abnormality rate was 11.6% one year after treatment. Conclusion:HbA1C can monitor IGR earlier,and is an efficacy index to the possible hyperglycemia in the treatment of antipsychotics when combined with routine fasting plasma glucose test. |
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| Keywords: | glycohemoglobin antipsychofics blood glucose |
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