淋巴瘤患者血清乳酸脱氢酶、碱性磷酸酶、总蛋白及白蛋白水平变化

目的研究血清乳酸脱氢酶（LDH）、碱性磷酸酶（ALP）、总蛋白（TP）和白蛋白（ALB）水平变化在淋巴瘤诊断中的价值。方法用日立7600全自动生化分析仪对226例淋巴瘤患者及50例健康人的LDH、ALP、TP和ALB水平进行检测。结果淋巴瘤患者血清LDH水平明显高于对照组（P〈0.05）,ALB水平明显低于对照组（P〈0.01）;霍奇金淋巴瘤（HL）组和弥漫性大B细胞瘤（DLBCL）组的ALP水平明显高于对照组,DLBCL组和其他淋巴瘤组的TP水平明显低于对照组。结论血清LDH、ALP、TP和ALB水平测定可作为淋巴瘤诊断的辅助指标,其中LDH、ALP和TP还可作为临床分期的辅助指标。

Serum levels of lactic dehydrogenase, alkaline phosphatase, total protein and albumin in patients with malignant lymphoma

Objective To study the value of serum lactic dehydrogenase（LDH）,alkaline phosphatase（ALP）,total protein（TP） and albumin（ALB） levels in diagnosis of malignant lymphoma.Methods Serum LDH,ALP,TP and ALB levels were measured in 226 patients with malignant lymphoma and 50 healthy controls using a Hitachi 7600 automatic biochemistry analyzer.Results The serum LDH level was significantly higher（P0.05） while the serum ALB level was significantly lower（P0.01） in patients with malignant lymphoma than in controls.The serum ALP level was significantly higher in patients with Hodgkin′s lymphoma（HL） and diffuse large B-cell lymphoma（DLBCL） than in controls while the serum TP level was significantly lower in patients with DLBCL and other types of lymphoma than in controls.Conclusion Serum LDH,ALP,TP and ALB levels can be used as accessory indicators in diagnosis of malignant lymphoma while serum LDH,ALP and TP levels can be used as accessory indicators for clinical staging.