代谢综合征与肱-踝脉搏波传导速度的相关性研究

目的分析查体人群肱-踝脉搏波传导速度（baPWV,Brachial-Ankle Pulse Wave Velocity）的变化与代谢综合征（MS,Metabolic Syndrome）及其它影响因素的关系。方法对某单位1003名查体人群统一进行代谢综合征评估（中华医学会糖尿病学会标准）并行baPWV检查。根据baPWV数值将男女各分4组,将相关代谢指标代入多元逐步回归方程,得到baPWV分级的独立危险因素。同时根据不同异常代谢组份数量,将男女各分5组,比较各组间baPWV差异。结果多元逐步回归分析提示在男性人群中年龄、收缩压、口服葡萄糖耐量试验（OGTT）2h血糖（2hBG）是baPWV分级的独立危险因素;在女性中年龄、收缩压、高血压史是baPWV分级的独立危险因素。在总体人群中,baPWV检测值随着异常代谢组份的增多而增加（P〈0.01）。结论年龄、收缩压、口服葡萄糖耐量试验2h血糖及高血压病史是baPWV的独立危险因素,随着代谢综合征异常组份的增多baPWV数值逐渐增加。

Correlation between metabolic syndrome and ankle-brachial pulse wave conduction velocity

Objective To analyze the correlation between ankle brachial pulse wave conduction velocity （baPWV） change and metabolic syndrome （MS） as well as other influencing factors in subjects at health examination. Methods MS was evaluated in 1 003 subjects during their health examination according to the criteria established by the Diabetes Mellitus Association under the Chinese Medical Association, and their BaPWV was detected. Male and female subjects were divided into 4 groups, respectively, according to their baPWV quartiles. Multiple-stepwise regression was employed to analyze the independent risk factors for baPWV grading. Male and female subjects were then divided into 5 groups, respectively, according to their abnormal metabolic components. Variance analysis was used to compare the differences in baPWV among the 5 groups. Results Multiple-stepwise regression revealed that age, systolic blood pressure （SBP）, oral glucose tolerance test （OGTT） 2h BG were the independent risk factors for baPWV grading in male subjects, while the age, SBP and hypertension history were the independent risk factors for baPWV grading in female subjects. The baPWV level increases with the increased abnormal metabolic components in all subjects（P0.01）. Conclusion Age, SBP, OGTT 2h BG, hypertension history are the independent risk factors for baPWV. BaPWV level increases the increased abnormal metabolic components.