雷公藤多苷片联合他扎罗汀治疗寻常型银屑病58例

目的:观察雷公藤多苷片联合他扎罗汀治疗寻常型银屑病的的临床疗效.方法:将116例寻常性银屑病患者随机分为观察组、对照组,每组58例.两组均外用他卡西醇软膏,2次/d;0.05％他扎罗汀凝胶,每日1次,睡前外用.观察组在对照组治疗的基础上口服雷公藤多苷片30 mg,每日3次.两组均以治疗4周为1个疗程,治疗3个疗程后观察临床疗效及治疗前后肿瘤坏死因子-α(TNF-α)、促血管内皮生成素(VEGF)、白介素-18(IL-18)水平及皮肤干燥、瘙痒、红斑、灼痛等不良反应的发生情况.结果:观察组基本痊愈率为51.72％,总有效率94.83％；对照组基本痊愈率37.93％,总有效率82.76％.两组基本痊愈率、总有效率相比差异有统计学意义(P＜0.05).TNF-α,VEGF,IL-18治疗前后两组组内相比差异具有统计学意义(P＜0.05),治疗后两组组间比较差异具有统计学意义(P＜0.05).观察组不良反应发生率10.34％,对照组不良反应发生率8.62％,两组相比差异无统计学意义.结论:雷公藤多苷片联合他扎罗汀治疗寻常型银屑病具有较好的临床疗效,可降低血清TNF-α,VEGF,IL-18的水平,使银屑病患者免疫调节趋向正常,从而达到治疗疾病的目的.

Effect of Tripterygium Wilfordii Tablets Combined Tazarotene in the Treatment of 58 Cases of Psoriasis Vulgaris

Objective: To observe the effect of tripterygium wilfordii tablets combined tazarotene in the treatment of psoriasis vulgaris in patients.Method: One hundred sixteen cases of psoriasis vulgaris patients were randomly divided into the observation group and the control group,58 cases in each group.Two groups were given topical tacalcitol ointment,bid;0.05% tazarotene gel,1 times a day,before going to bed externally.Observation group was treated with tripterygium wilfordii polyglycoside tablet 30 mg each time,tid.The 2 groups were treated for 4 weeks as 1 courses of treatment.After 3 courses of treatment clinical effect was observed for before and after treatment,including tumor necrosis factor-α(TNF-α),expression of vascular endothelial growth factor(VEGF),interleukin 18(IL-18) and dry skin,itching,erythema,burning and other adverse reaction.Result: In observation group basic recovery rate was 51.72%,total effective rate was 94.83%;in control group the basic recovery rate was 37.93%,the total efficiency of 82.76%.Two groups showed significant basic recovery rate and the total efficiency rate(P<0.05).TNF-α,VEGF,IL-18 before and after treatment in 2 groups both showed difference(P<0.05).After the treatment,the difference between two groups was significant(P<0.05).In observation group the incidence of adverse reactions was 10.34%,in control group the incidence was 8.62% without significant difference.Conclusion: The effect of Tripterygium wilfordii tablets combined tazarotene in the treatment of psoriasis vulgaris has good clinical curative effect,can reduce the level of serum TNF-α,VEGF,IL-18 levels,so that psoriasis patients immune regulation tends to normal,so as to achieve the purpose of treating disease.