熊胆粉联合西药治疗婴儿巨细胞病毒感染相关胆汁淤积性肝炎

目的:评价熊胆粉联合更昔洛韦治疗婴儿巨细胞病毒(CMV)感染相关胆汁淤积性肝炎的治疗效果.方法:将46例婴儿巨细胞病毒感染相关胆汁淤积性肝炎患儿随机分为治疗组24例与对照组22例.两组均给予更昔洛韦5 mg·kg-1,12 h/次等综合对症治疗.治疗组在此基础上加用熊胆粉0.02 g·kg-1口服,2次/d,均连用14 d,观察结果.结果:治疗组治疗前后比较血清总胆汁酸、血清总胆红素、直接胆红素、肝内胆管宽度差异有统计学意义(P＜0.01),对照组治疗前后直接胆红素、胆汁酸、肝内胆管宽度无统计学意义；两组黄疸开始消退时间、黄疸完全消退时间之间差异有非常显著性意义(P＜0.01).结论:熊胆粉可以降低总胆红素和直接胆红素,降低胆汁酸水平,减轻肝功能损伤,减轻胆管扩张,促进黄疸消退.

Clinical Observation of Infantile Cytomegalovirus Hepatitiswith Cholestasis Treated with Powder of Bear Gallbladder

Objective :To evaluate the therapeutic effects of powder of bear gallbladder combined with ganciclovir in infantile cytomegalovirus hepatitiswith cholestasis. Method :Rorty-six infantiles cytomegalovirus hepatitiswith cholestasis were randomly divided into tow groups: the treatment group (n=24)and the control group(n=22). The treatment group received powder of bear gallbladder (0.02 g·kg^-1) once day orally,ganciclovir was given in the two groups for two weeks. Result: There were significant differences in IBIL and TBA between the two groups after two weeks (P<0.01).There were very significant differences in time of initial jaundice disappearance and complete disappearance after two weeks (P<0.01). Conclusion :As external ademetionine,powder of bear gallbladder could supplement absent endogenous ademetionine,efficiently decrease intestine- liver circulation,protect scathing liver cell and accelerate jautice to fade away.