Diurnal rhythm in cyclic GMP/nitric oxide efflux in the medial preoptic area of male rats |
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| Authors: | Shuye Pu Pushpa S Kalra Satya P Kalra |
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| Affiliation: | aUniversity of Florida Brain Institute, Gainesville, FL 32610, USA;bDepartment of Neuroscience, University of Florida College of Medicine, Gainesville, FL 32610, USA;cDepartment of Physiology, University of Florida College of Medicine, Gainesville, FL 32610, USA |
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| Abstract: | Since nitric oxide (NO) is implicated in the neuroendocrine control of luteinizing hormone-releasing hormone (LHRH) secretion and sexual behavior which show diurnal variations, we monitored cGMP levels (an index of NO activity) in the extracellular compartment of the medial preoptic area (MPOA) using microdialysis. It was observed that MPOA cGMP levels rose significantly in the afternoon in both castrated and intact male rats, thereby suggesting the existence of a diurnal rhythm in MPOA cGMP/NO efflux which may participate in eliciting the well-known diurnal variations in LHRH neuronal activity and male sexual behavior. |
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| Keywords: | Nitric oxide Cyclic GMP Diurnal rhythm Medial preoptic area |
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