National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease |
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| Authors: | Hyman Bradley T Phelps Creighton H Beach Thomas G Bigio Eileen H Cairns Nigel J Carrillo Maria C Dickson Dennis W Duyckaerts Charles Frosch Matthew P Masliah Eliezer Mirra Suzanne S Nelson Peter T Schneider Julie A Thal Dietmar Rudolf Thies Bill Trojanowski John Q Vinters Harry V Montine Thomas J |
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| Affiliation: | Department of Neurology, Massachusetts General Hospital, Harvard University, Boston, MA, USA. |
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| Abstract: | A consensus panel from the United States and Europe was convened recently to update and revise the 1997 consensus guidelines for the neuropathologic evaluation of Alzheimer's disease (AD) and other diseases of brain that are common in the elderly. The new guidelines recognize the pre-clinical stage of AD, enhance the assessment of AD to include amyloid accumulation as well as neurofibrillary change and neuritic plaques, establish protocols for the neuropathologic assessment of Lewy body disease, vascular brain injury, hippocampal sclerosis, and TDP-43 inclusions, and recommend standard approaches for the workup of cases and their clinico-pathologic correlation. |
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