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Association of a single-nucleotide polymorphism in the promoter region of leukemia inhibitory factor receptor gene with low bone mineral density in adult women |
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| Authors: | Yoshihiro Sudo Yoichi Ezura Ryota Ishida Mitsuko Kajita Hideyo Yoshida Takao Suzuki Takayuki Hosoi Satoshi Inoue Masataka Shiraki Hajime Orimo Hiromoto Ito Mitsuru Emi |
| Affiliation: | Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, Kawasaki,; Tokyo Metropolitan Institute of Gerontology and Geriatric Hospital,; Department of Geriatric Medicine, Faculty of Medicine, University of Tokyo, and; Department of Orthopaedics, Nippon Medical School, Tokyo and; Research Institute and Practice for Involutional Diseases, Nagano, Japan |
| Abstract: | Background: Osteoporosis is believed to result from the interaction among multiple environmental and genetic determinants that regulate bone-mineral density (BMD). Methods: To investigate a potentially predisposing genetic factor in the onset of osteoporosis, we looked for a possible association between BMD in adult Japanese women and known polymorphisms in the leukemia inhibitory factor receptor gene (LIFR). Results: An association analysis of chromosomes from 384 volunteer subjects revealed significant correlation between the −603T > C variant of LIFR and radial BMD ( r = 0.11, P = 0.032) in this test population. Comparisons of mean values of adjusted radial BMD among separate genotypic groups implied an allelic dosage effect, because homozygous carriers of T alleles of that SNP had the highest adjusted BMDs (0.403 ± 0.054 g/cm Conclusion: This polymorphism in LIFR may be an important determinant of predisposition to postmenopausal osteoporosis. |
| Keywords: | bone mineral density leukemia inhibitory factor receptor (LIFR) osteoporosis regression analysis single-nucleotide polymorphism |