Capecitabine in combination with irinotecan (XELIRI), administered as a 2-weekly schedule, as first-line chemotherapy for patients with metastatic colorectal cancer: a phase II study of the Spanish GOTI group |
| |
Authors: | P Garcia-Alfonso A Mu?oz-Martin M Mendez-Ure?a R Quiben-Pereira E Gonzalez-Flores G Perez-Manga |
| |
Institution: | 1Medical Oncology Service, Hospital General Universitario Gregorio Marañón, Doctor Esquerdo 46, Madrid 28007, Spain;2Medical Oncology Service, Hospital Universitario de Móstoles, Río Júcar s/n, Móstoles, Madrid 28935, Spain;3Medical Oncology Service, Hospital Universitario Virgen de las Nieves, Avda. Fuerzas Armadas 2, Granada 18014, Spain |
| |
Abstract: | Background: Combination chemotherapy is standard treatment for metastatic colorectal cancer (MCRC). The aim of this study was to determine the efficacy and safety of capecitabine+irinotecan (2-weekly schedule), as first-line therapy of MCRC.Methods: Patients received irinotecan 175?mg?m?2 on day 1 and oral capecitabine 1000?mg?m?2 twice daily on days 2–8 every 2 weeks. For patients aged ?65 years, the starting doses of irinotecan and capecitabine were reduced to 140 and 750?mg?m?2, respectively.Results: A total of 53 patients were enrolled: 29 (55%) were ?65 years old. In an intention-to-treat analysis, complete response was achieved in three patients for an overall response rate (ORR) of 32%. The disease control rate (ORR + stable disease) was 66% and the median duration of response was 7.3 months. Median time to progression and overall survival were 9.0 and 19.2 months, respectively. Grade 4 neutropenia was reported in one patient: no other grade 4 toxicities were recorded. Grade 3 diarrhoea occurred in 8 (15%) patients and grade 1–2 hand–foot syndrome in 7 (13%) patients.Conclusion: Capecitabine and irinotecan, given every 2 weeks, as first-line treatment of MCRC is an active regimen with a manageable toxicity profile, even in older patients. |
| |
Keywords: | capecitabine colorectal cancer combined modality therapy irinotecan |
|
|