Acute toxicity of monochlorophenols, dichlorophenols and pentachlorophenol in the mouse |
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Authors: | J F Borzelleca J R Hayes L W Condie J L Egle |
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Affiliation: | 2. Department of Pharmacology and Toxicology, Medical College of Virginia, Box 613, Virginia Commonwealth University, Richmond, VA 23298 USA;1. U.S. Environmental Protection Agency, 26 W. St. Clair Street, Cincinnati, OH 45268 U.S.A. |
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Abstract: | Acute oral LD50 values were determined for 2-, 3-, and 4-chlorophenol, 2,3-, 2,4-, 2,5-, 2,6-, 3,4-, and 3,5 dichlorophenol and pentachlorophenol in male and female mice. LD50 values (mg/kg) ranged from 117 (females) and 177 (males) for pentachlorophenol to 2389 (females) and 2643 (males) for 3,5-dichlorophenol. It was found that 2-chlorophenol and 3-chlorophenol were considerably more toxic than the dichlorophenol series. Values for males and females were generally similar, the major differences being with pentachlorophenol and 2,5-dichlorophenol, where in both cases the female LD50 was lower. |
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Keywords: | Chlorophenols acute toxicity mice |
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