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| 乳腺癌组织中Survivin 和VEGF的表达及意义 | |
| 引用本文： | 张旭宏,张贞玲,崔滨滨.乳腺癌组织中Survivin 和VEGF的表达及意义[J].黑龙江医药科学,2006,29(6):38-39. |
| 作者姓名： | 张旭宏 张贞玲 崔滨滨 |
| 作者单位： | 1. 佳木斯大学附属第二医院,黑龙江,佳木斯,154003 2. 佳木斯市中心医院,黑龙江,佳木斯,154002 3. 哈医大附属三院,黑龙江,哈尔滨,150000 |
| 摘 要： | 目的:研究抗凋亡蛋白Survivin、血管内皮生长因子VEGF在乳腺癌中的表达情况,探讨二者与乳腺癌侵袭的关系以及二者之间的联系.方法:应用免疫组织化学方法检测Survivin 和VEGF在41例乳腺癌标本中和10例正常乳腺组织对照组的表达情况.结果:乳腺癌中Survivin的阳性表达(68.29%),VEGF的阳性表达(63.41%),明显高于对照组中的表达,且他们的表达与肿瘤的淋巴结转移和c-erBb-2有相关性.Survivin表达与VEGF表达呈明显正相关(P＜0.01).结论:Survivin与VEGF的表达在乳腺癌的发生、发展中起重要作用.Survivin的高表达促进了VEGF的促内皮细胞功能. |
| 关 键 词： | 乳腺癌 Survivin VEGF 免疫组化 |
| 文章编号： | 1008-0104-(2006)06-0038-02 |
| 修稿时间： | 2006年9月17日 |
Expression of Survivin and VEGF in breast cancer and their relations |
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| ZHANG Xu-hong,ZHANG Zhen-ling,CUI Bin-bin.Expression of Survivin and VEGF in breast cancer and their relations[J].Heilongjiang Medicine and Pharmacy,2006,29(6):38-39. | |
| Authors: | ZHANG Xu-hong ZHANG Zhen-ling CUI Bin-bin |
| Abstract: | Objective:To study the expression of Survivin and VEGF in the breast carcinoma tissue,and their relations to the carcinoma invasion.Methods:By using immunohistochemistry,we detected the expression of Survivin and VEGF in 41 cases of breast cancer and the breast tissue of 10 normal subjects.Results:The positive expression of Survivin and VEGF in breast cancer was higher than that of normal breast tissue(P<0.05).Their expression was correlated with lymph node metastasis and c-erBb-2,and Survivin expression was positively related to VEGF expression.Conclusion:The expression of Survivin and VEGF may play an important role in the occurrence and development of breast carcinoma.The higher expression of Survivin helps VEGF promote the growth of the endothelial cells. |
| Keywords: | breast carcinoma Survivin VEGF immunohistochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |