胃舒康胶囊对消化性溃疡作用的研究

目的研究胃舒康胶囊对消化性溃疡的作用。方法采用利血平、幽门结扎和乙酸溃疡模型,分别用胃舒康混悬液灌胃。利血平和幽门结扎溃疡模型连续灌胃7d,复制溃疡模型,计算溃疡指数。乙酸溃疡模型造模后,连续灌胃12d取胃,计算溃疡指数。镇痛实验采用热板法和扭体法,用药方法同上。分别测定各组小鼠的痛阈、扭体反应潜伏期和15min内扭体反应的次数。临床观察107例患者,实验组服胃舒康胶囊,每日3次,每次5粒,对照组服雷尼替丁,每次15mg,每日2次,以评价治疗作用。结果胃舒康对实验性胃溃疡有治疗作用,与对照组比较有显著性差异(P<0.05);能显著提高痛阈、延长小鼠扭体反应的潜伏期和减少扭体反应次数,与对照组比较有显著性差异(P<0.05)。临床治疗症状改善有效率实验组为91%,对照组92%;溃疡愈合率实验组72.5%,对照组79.4%,两组对临床症状的改善率及对消化性溃疡的治疗无显著性差异(P>0.05)。结论胃舒康胶囊对胃粘膜有保护作用,治疗消化性溃疡疗效确切。

Study of Weishukang Capsule's Effect on Digestive Ulcer

Objective To study the Weishukang capsule's effect on digestive ulcer. Methods Rats were given respectively suspended Weishukang by ig reserpine,ligating pylorus and acetic acid gastric ulcer's,given consecutively 7 days,copy the (ulcer's) models calculate the index of the ulcer.The medicines were given consecutively 12 d and then the stomaches were taken out and calculated the index of the ulcer after the acetic acid ulcer models were made.The analgesic experiment was conducted by hot-plate method and twisting-body method,the method of giving the medicine as the above.Determine respectively each group of mice's pain limits,the latent period and times (within 15 min) of twisting-body reactions.107 patients were observed clinically.Experimental group took Weishukang,3 times a day,5 pills each time;control group took ranitidine 15 mg each time,twice a day,checked by endoscope within one week after one course of treatment so as to evaluate the therapeutic effect. Result Weishukang had therapeutic effect on experimental gastric ulcer and had significant difference ((P<0.05)) compared with the control group;could increase the pain limits remarkably, prelong the latent period and reduce the time of twisting-body reaction of mice ((P<0.05)).The effective rate of symptomatic improvement through clinical treatment was 91% in experimental group,92% in the positive control group;the ulcer's healing rate was 72.5% in the experimental group,79.4% in the positive control group,the two groups both had no significant differences in the effective rate of clinical symptom as well as the treatment of digestive ulcer ((P<0.05)). Conclusion Weishukang has protective effect on gastric mucosa. Weishukang has a definite therapeutic effect on digestive ulcer.