Asymmetrische reduktive Aminierung von Cycloalkanonen, 3. Mitt. Der Einfluß von Katalysator und Reduktionsmittel auf die Diastereo- und Enantioselektivität

Asymmetric Reductive Amination of Cycloalkanones, III: Influence of Catalyst and Reducing Agent on the Diastereo- and Enantioselectivity The dependence of diastereo- and enantioselectivity in the asymmetric reductive amination of racemic 2-methylcyclohexanone ( 1 ) on the type of catalyst and reducing agent has been investigated. Diastereo- and enantioselectivity were determined by ¹³C-NMR spectroscopy. Raney nickel proved to be the catalyst of choice. With Pd/C the campherazomethines 5 are hydrogenated and simultaneously hydrogenolized to yield the 2-exo-aminobornanes 6 .