新型冠状病毒相关性急性胰腺炎的认识现状

新型冠状病毒肺炎（简称新冠肺炎）依然在全球肆虐,有关新冠肺炎的文献报道呈指数增长,其中已有病例报道、回顾性研究以及生物信息学数据开始关注新冠肺炎与急性胰腺炎的关联。新冠病毒攻击胰腺的具体机制尚不明确,但新冠病毒受体在胰腺组织中的表达已被证实,且在新冠肺炎患者的胰腺组织中可分离出新冠病毒成分。这些均提示新冠病毒与急性胰腺炎之间可能存在因果联系。新冠病毒相关性急性胰腺炎临床上易被漏诊,其诊断、严重程度分级及预后均都具有一定的特殊性,值得特别关注。

Current knowledge of SARS-CoV-2 associated acute pancreatitis

The global pandemic of coronavirus disease 2019 (COVID-19) is still ongoing, and the literature concerning COVID-19 is growing exponentially. The existing data from case reports, retrospective cohort studies and bioinformatics have suggested the relationship between SARS-CoV-2 and acute pancreatitis (AP). The mechanism of how SARS-CoV-2 attacks pancreas remains unclear. However, the expression of the receptor of SARS-CoV-2 in pancreatic tissue has been confirmed, and the components of SARS-CoV-2 have been isolated in the pancreas from patients with COVID-19. These evidences indicate that there may be a causality between SARS-CoV-2 and AP. The SARS-CoV-2 associated acute pancreatitis (SAAP) is likely to be misdiagnosed in clinical settings. Its diagnosis, severity classification and prognosis have specificities that deserve special attention.