骨髓间充质干细胞结合Masquelet技术治疗感染性骨缺损的临床疗效观察

目的 观察应用骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSCs)结合Masquelet技术治疗感染性骨缺损的临床疗效.方法 回顾性分析2016年6月至2019年1月河南省洛阳正骨医院采用BMSCs结合Masquelet技术治疗的30例感染性骨缺损病人的临床资料.其中男2...

Effectiveness of Bone Marrow Mesenchymal Stem Cells Combined with Masquelet Technique in the Treatment of Infectious Bone Defect

Objective To observe the clinical effectiveness of bone marrow mesenchymal stem cells (BMSCs) combined with Masquelet technique in the treatment of infectious bone defect. Methods From June 2016 to January 2019, 30 patients with infectious bone defect were treated with BMSCs combined with Masquelet technique. In the first stage, the infected and necrotic bone tissue, soft tissue and scar tissue with poor blood supply were removed, the bone cement interval was filled, the wound was covered, and the fracture was fixed. In the second stage, the bone cement interval was removed 8-10 weeks after operation, and the induced membrane was filled with BMSCs combined with autologous bone and artificial bone graft. The fracture healing time of all patients was recorded, and the Johner-Wruhs scoring system was used to evaluate the bone defect healing at the last follow-up. Results All patients were followed up for 8-25 months (mean 15.5 months). The average time of bone defect healing was 9.4 (6-15) months in 28 patients. One case of postoperative infection relapsed and healed after repeated application of induced membrane technique. One case showed incomplete fracture healing after 12 months of reexamination, and healed after the second iliac bone graft. According to Johner-Wruhs scoring system, 27 cases were excellent, 2 cases were good, 1 case was fair, and the excellent and good rate was 96.7%. Conclusion BMSCs combined with Masquelet technique are effective in the treatment of infectious bone defect, which is a feasible method.