羌活药材的化学成分和药理活性研究进展

羌活为伞形科植物羌活Notopterygium incisum或宽叶羌活Notopterygium franchetii干燥后的根茎和根,从其中分离得到的主要化学成分包括挥发油及萜类、香豆素类、糖及糖苷类、酚酸类、聚烯炔、生物碱类等。药理研究表明,羌活具有抗炎抗菌、抗氧化、抗病毒、抗癌细胞增殖、解热镇痛等活性,且对心脑血管系统、消化系统、呼吸系统和中枢神经系统有显著影响。主要介绍中药羌活的化学成分及药理活性研究进展,并对其研究方向进行展望,为进一步研究其药效物质基础、作用机制及合理开发利用提供理论依据。

Research progress on chemical constituents and pharmacological activities of Notopterygii Rhizoma et Radix

Notopterygii Rhizoma et Radix consists of two species of Notopterygium (Umbelliferae), N. incisum Ting ex H. T. Chang and N. forbesii De Boiss. The main chemical constituents isolated from this herb include volatile oils and terpenes, coumarins, sugars, glycosides, phenolic acids, polyalkynes and alkaloids. Pharmacological studies have shown that Notopterygii Rhizoma et Radix has anti-inflammatory, antibacterial, antioxidant, antiarrhythmic, and anti-cancer, antipyretic and analgesic activities, and has positive effects on the cardiovascular, digestive, respiratory and central nervous systems. This review mainly summarized the research progress of the main chemical constituents and pharmacological activities of Notopterygii Rhizoma et Radix, and prospected its research direction, and provided theoretical basis for further research on its substance basis, mechanisms of pharmacological actions, reasonable development and utilization.