含奥沙利铂方案介入治疗中晚期肝癌的疗效研究

目的探讨含奥沙利铂方案介入治疗中晚期肝癌的疗效、不良反应。方法159例中晚期肝癌患者随机分2组。研究组79例,行含奥沙利铂方案介入治疗;对照组80例,行常规介入治疗,比较2组疗效和副作用。结果研究组瘤体缩小近期有效率为72.2%(57/79),较对照组51.3%(41/80)有显著性差异(P<0.05)。研究组甲胎蛋白下降幅度分别为73.3%(33/45),较对照组43.1%有显著性差异(P<0.05)。主要毒副反应为胃肠道反应及骨髓抑制。结论含奥沙利铂方案介入治疗中晚期肝癌具有较高的疗效,毒反应发生率低。

Clinical effect of oxaliplatin-containing regimen in TACE of advanced hepatocellular carcinoma

Objective To explore the clinical effect and side-effect of oxaliplatin-containing regimen in TACE of advanced hepatocellular carcinoma. Methods 159 patients were divided randomly into experimental group (n=79, oxaliplatin EPI 5-FU) and control group (n=80, MMC EPI 5-FU). The clinical effect and side-effect of two groups were studied. Results The total effective rate of experimental group was 72.2% (57/79),and that of control group was 51.3% (41/80), and the difference was significant (P<0.05). The descent rate of AFP of experimental group was 73.3% (33/45), and that of control group was 43.1% (22/51), and the difference was significant (P<0.05). The main side effects were gastrointestinal tract side-effect and leukopenia. Conclusions Oxaliplatin-containing regimen in TACE of advanced hepatocellular carcinoma is an efficient method with fewer side effects.