Surprise! HSC are aberrant in chronic lymphocytic leukemia |
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| Authors: | Alizadeh Ash A Majeti Ravindra |
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| Affiliation: | Institute for Stem Cell Biology and Regenerative Medicine, Cancer Institute, and Division of Hematology, Department of Internal Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA. arasha@stanford.edu |
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| Abstract: | In this issue of Cancer Cell, Kikushige et?al. report the surprising finding that, in human chronic lymphocytic leukemia (CLL), hematopoietic stem cells (HSC) aberrantly generate clonal B cells with CLL-like phenotypes, which implicate HSC in the pathogenesis of this mature lymphoid malignancy and has major implications for CLL therapies. |
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