Successful treatment of ulcerative colitis associated with hypereosinophilic syndrome/chronic eosinophilic leukemia |
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Authors: | Awano Nobuyasu Ryu Tomiko Yoshimura Naoki Takazoe Masakazu Kitamura Shigehiro Tanaka Masanori |
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Affiliation: | Department of Internal Medicine, Social Insurance Chuo General Hospital, Japan. |
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Abstract: | A 23-year-old female was diagnosed as having simultaneous ulcerative colitis (UC) relapse and hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL) without FIP1L1-platelet-derived growth factor receptor alpha (PDGFRA) (F/P) fusion gene. Pathological findings of colon specimens were compatible with UC, however, focal severe infiltration of eosinophils was observed in the rectum, which is unusual in UC, suggesting eosinophil-mediated organ damage. Although imatinib mesylate (IM) is usually ineffective for the treatment of HES/CEL with negative-F/P fusion gene, in the present case it led to the remission of HES/CEL and UC at a higher drug dosage level (400 mg/day). That suggested the presence of unknown tyrosine kinase abnormalities not yet categorized. |
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