Antiviral triterpenes fromPrunella vulgaris |
| |
Authors: | Shi Yong Ryu Chong-Kyo Lee Chong Ock Lee Hae Soo Kim Ok Pyo Zee |
| |
Affiliation: | 1. Korea Research Institute of Chemical Technology, 305-606, Taejeon, Korea
|
| |
Abstract: | Two triterpenes 1 and 2 with antiviral activity againstHerpes simplex virus type 1in vitro were isolated fromPrunella vulgaris. Each compound caused a significant reduction in viral cytopathic effect whenvero cells were exposed to them for 72 hours after viral challenge. They were identified asbetulinic acid(1) and 2α, 3α-dihydroxyurs-12-en-28-oic acid(2) on the basis of their spectroscopic properties. The antiviral activity of them was estimated as EC50=30 μg/ml(1) and 8 μg/ml(2), respectively by plaque reduction assay. |
| |
Keywords: | Prunella vulgaris Labiatae betulinic acid 2α ,3α -dihydroxyurs-12-en-28-oic acid antiviral Herpes simplex |
本文献已被 SpringerLink 等数据库收录! |