Decrease of CD154 intensity on peripheral CD4+ T cells in autoimmune thyroid disease |
| |
Authors: | Watanabe M Yamamoto N Matsuzuka F Miyauchi A Iwatani Y |
| |
Institution: | Division of Biomedical Informatics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. |
| |
Abstract: | To clarify immunological differences among patients with Graves' disease (GD) and Hashimoto's disease (HD) at various levels of severity, we examined the expression of the CD154 molecules on peripheral T cells, which regulate B cell activation, B cell differentiation, and T-cell survival. We found decreases in the intensities of CD154 on peripheral CD4(+) cells from euthyroid patients with GD and HD, but we did not find any differences between patients with different disease severities. CD8(+) cells did not express CD154 molecules. Thus, CD154 expression on CD4(+) cells may be related to the pathogenesis of the autoimmune thyroid diseases, not to the disease severity. |
| |
Keywords: | disease severity antigen presenting cell CD40 ligand Fas ligand |
本文献已被 PubMed 等数据库收录! |
|