甲基泼尼松龙冲击治疗Balo病

目的观察甲基泼尼松龙冲击疗法（MP胛）治疗Balo病的近期及远期临床疗效。方法18例Balo病患者，均经过临床及头颅MRI有特异性表现所明确诊断。成人采用甲基泼尼松龙（MP）1000mg／d，儿童20mg·kg^-1·d^-1）加入5％葡萄糖1000ml溶液内静脉缓慢滴注，连用3d为1疗程，每月1疗程，共3个疗程。结果近期临床疗效（3个月内）为：显效12例（66．7％），有效4例（22．2％），无效2例（11．1％）；临床观察6个月、1年、2年和3年时临床缓解率均为72．2％。结论MPPT治疗Balo病3个月．3年长期缓解率较高，6月内无缓解的预后差，有疗效的患者采用小剂量泼尼松龙可以取得较长的缓解时间，有一定的临床实用和推广价值。

Eighteen patients of Balo disease treated by methylprednisolone pulse therapy

Objective To evaluate the therapeutic effect of Balo disease treated by methylprednisolone pulse therapy (MPPT) including the followed-up of recent clinical efficacy and long-term clinical efficacy.Methods Eighteen patients of Balo disease used MPPT and were diagnosed to undergo a brain MRI and clinical performance of a specific.The adult dose used was methylprednisolone(MP) 1 000 mg /d,and the children dose was 20 mg/(kg·d) by adding 5% glucose solution with 1 000 ml slowly intravenous drip.Three days of continuous use was a course of treatment per month,a total of three treatments.Results The recent curative effect (within 3 months after treatment) was as follows:twelve cases (66.7%) acquired a significant effect,four cases (22.2%) patients'conditions were improved,and two cases (11.1%) had no effect.The rate increased to 72.2% after retesting at 6 months,1 year,2 years and 3 years.Conclusion Most Balo disease patients treated with MPPT had acquired perfectly curative effect from 6 months to 3 years after treatment.However,some did not acquire a good effect in six months and became worse.The patients with therapeutic use of low-dose prednisone can have a longer remission time.This method has some clinical utility value and should be promoted as useful.