肝星状细胞在肝细胞癌形成和发展中的作用

肿瘤的发生、侵袭及转移是长久以来备受关注的问题,肿瘤细胞与其周围基质物质的关系作为其中的关键因素愈加收到重视,肝星状细胞(HSC)作为肝癌微环境中的重要组成部分,在"炎症-肝纤维化/肝硬化-肿瘤"这一发生发展过程中充当了重要的介质。介绍了HSC的来源及其活化过程,并进一步阐述HSC自身与其分泌的多种细胞因子在肝细胞癌增殖、迁移、侵袭过程中对机体免疫反应发挥的作用。认为HSC不仅是肿瘤生长的"温床",也为肿瘤抵御了免疫系统的追踪和清除。因此在单一抗肿瘤治疗无法取得明显效果时,对于肝癌微环境的多方位治疗成为值得探讨的方案。

The role of hepatic stellate cells in development and progression of hepatocellular carcinoma

A growing body of literature highlights the cross - talk between tumor cells and the surrounding peritumoral stroma as a key modu lator in the development, invasion, and metastasis of hepatocellular carcinoma （HCC）. Hepatic stellate cells （ HSC）, an important compo nent in the microenvironment of HCC, play an important role in the development and progression of ＂inflammation - fibrosis/cirrhosis - tumor＂. The origin and activation of HSC, as well as the effects of HSC and their cytokines on the immune response in the proliferation, me tastasis, and invasion of HCC, are reviewed. It is thought that HSC are not only a ＂hotbed＂ for tumor growth, but also help resist the tumor tracing and elimination mechanism of the immune system. Therefore, it is worth developing treatments targeting the tumor microenvironment when the single anti - cancer therapy is ineffective.