| 水蛭注射液抗血栓与抗凝血作用 |
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| 引用本文： | 钟山,崔征,王东,李建林,翟岩. 水蛭注射液抗血栓与抗凝血作用[J]. 沈阳药科大学学报, 2006, 23(7): 456-458 |
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| 作者姓名： | 钟山 崔征 王东 李建林 翟岩 |
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| 作者单位： | 沈阳药科大学,中药学院,辽宁,沈阳,110016 |
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| 摘 要： | 目的研究水蛭注射液的抗血栓和抗凝血作用。方法采用体外血栓法、纤维蛋白平板法及全血血块法,观察水蛭注射液的抗血栓作用;采用家兔血浆复钙时间法、凝血酶时间法及凝血酶原时间法,观察水蛭注射液的抗凝血作用。结果水蛭注射液高剂量(1.0 kg.L-1)、中剂量(0.5 kg.L-1)和低剂量(0.25 kg.L-1)均能明显溶解体外血栓(P<0.001)、纤维蛋白平板(P<0.001)和全血凝块(作用显著);能显著延长家兔血浆复钙时间、凝血酶时间和凝血酶原时间(P<0.001)。结论水蛭注射液具有较强的抗血栓和抗凝血作用。
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| 关 键 词： | 水蛭注射液 血栓 纤维蛋白平板 血浆复钙时间 凝血酶时间 凝血酶原时间 |
| 文章编号： | 1006-2858(2006)07-0456-03 |
| 收稿时间： | 2005-09-01 |
| 修稿时间： | 2005-09-01 |
Antitrombotic and anticoagulation effects of Leech injection |
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| ZHONG Shan,CUI Zheng,WNAG Dong,LI Jian-lin,ZHAI Yan. Antitrombotic and anticoagulation effects of Leech injection[J]. Journal of Shenyang Pharmaceutical University, 2006, 23(7): 456-458 |
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| Authors: | ZHONG Shan CUI Zheng WNAG Dong LI Jian-lin ZHAI Yan |
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| Abstract: | Objective To study the antitrombotic and anticoagulation effects of Leech injection(LI).Methods The antitrombotic effect of LI was studied by means of thrombus in vitro,fibrin plate and whole blood-gore.The anticoagulation effect of LI was determined by means of plasma recalcificatic time,thrombon time and prothrombon time.Results All of three dosages of LI(1.0 g·mL~(-1),0.5 g·mL~(-1) and 0.25 g·mL~(-1)) could not only dissolve the thrombus in vitro(P<0.001),normal or heated fibrin plate(P<0.001)and whole blood-gore(remarkably),but also prolong the plasma recalcificatic time,thrombon time and prothrombon time(P<0.001).Conclusions LI has potent antitrombotic and anticoagulation activities. |
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| Keywords: | Leech injection thrombus fibrin plat plasma recalcificatic time thrombon time prothrombon time |
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