| 硫酸头孢噻利在复方氨基酸注射液中稳定性考察 |
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| 引用本文： | 吕碧华,朱雅艳,田伟强,张颖异. 硫酸头孢噻利在复方氨基酸注射液中稳定性考察[J]. 中国药业, 2012, 21(3): 5-6 |
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| 作者姓名： | 吕碧华 朱雅艳 田伟强 张颖异 |
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| 作者单位： | 浙江省丽水市中心医院,浙江丽水,323000 |
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| 摘 要： | 目的 考察注射用硫酸头孢噻利在复方氨基酸注射液(18AA)中的配伍稳定性.方法 分别在4,25,37℃下考察配伍液6 h内外观、pH的变化,同时采用反相高效液相色谱法测定配伍液中硫酸头孢噻利的含量变化.结果 在4,25,37℃下,配伍液6 h内外观、pH、含量无明显变化.结论 硫酸头孢噻利可与复方氨基酸注射液(18AA)配伍,配伍后于4,25,37℃下6 h内均可使用.
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| 关 键 词： | 高效液相色谱法 硫酸头孢噻利 配伍 稳定性 |
Compatible Stability of Cefoselis Sulfate Injection in Compound Amino Acid Injection |
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| Lü Bihua,Zhu Yayan,Tian Weiqiang,Zhang Yingyi. Compatible Stability of Cefoselis Sulfate Injection in Compound Amino Acid Injection[J]. China Pharmaceuticals, 2012, 21(3): 5-6 |
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| Authors: | Lü Bihua Zhu Yayan Tian Weiqiang Zhang Yingyi |
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| Affiliation: | (Department of Pharmacy, Lishui Central Hospital, Lishui, Zhejiang , China 323000) |
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| Abstract: | Objective To study the compatible stability of Cefoselis Sulfate Injection in Compound Amino Acid injection. Methods To study the mixed fluid changes in appearance, pH value within 6 h at 4,25,37℃, and to determine the content of cefoselis sulfate in Compound Amino Acid Injection and in Dextran 40 Glucose injection by RP- HPLC. Results There were no evident changes in appearance, pH value and the content of the mixed fluid within 6 h at 4,25,37 %. Conclusion The Cefoselis Sulfate Injection in Compound Amino Acid Injection can be mixed to use within 6 h under 4,25,37 ℃. |
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| Keywords: | HPLC cefoselis sulfate compatible stability |
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