固体脂质纳米粒作为水杨酸经皮给药载体的研究

目的 考察固体脂质纳米粒作为经皮给药载体对水杨酸经皮吸收的促渗透作用.方法 采用薄膜超声法制备水杨酸固体脂质纳米粒,以改良的Franz扩散池考察其体外透皮特性;并与水杨酸软膏剂比较,考察其促渗作用.结果 制备的水杨酸固体脂质纳米粒均匀圆整,包封率为46.4%,体外透皮特性优于普通软膏剂,24 h后皮肤药物累积透过量为654.3 μg/cm2,皮肤中药物残留量为22.99 μg,均分别显署高于软膏剂组(128.0 μg/cm2和0.84 μg,P<0.05).结论 固体脂质纳米粒作为水杨酸经皮给药载体,可有效促进药物透皮吸收和增加药物在皮肤中储留量,而且可延缓药物的释放,从而有效提高药物疗效及患者依从性.

Study on Solid Lipid Nanoparticle as Carrier for Transdermal Delivery of Salicylic Acid

Objective To investigate the permeation enhancing effect of solid lipid nanoparticles（SLN） on the transdermal delivery of salicylic acid（SA）.Methods The SA-SLN was prepared by the film-ultrasonic method and its in vitro penetration characteristics was assessed by the modified Franz diffusion cells and compared with the ointment for investigating the permeation enhancing effect.Results The prepared SA-SLN was spherical in shape with the entrapment rate of 46.4%.Its in vitro transdermal permeation characteristics was superior to the common ointment with accumulate penetration amount of 654.3 μg/cm2 and the drug residual amount of 22.99 μg in skin after 24 h,which were significantly higher than the ointment′s respectively（128.0 μg/cm2 and 0.84 μg,P 0.05）.Conclusion SLN as the carrier for transdermal delivery of salicylic acid can not only effectively promote the transdermal absorption and increase the drug retention amount in skin,but also delays the drug release to effectively enhance the medication efficacy and patient compliance.