Therapeutic and clinico-pathological factors in the survival of 1,469 patients with primary cutaneous malignant melanoma in clinical stage I |
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Authors: | Knud Søndergaard Geert Schou |
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Affiliation: | (1) Department of Pathology, The Finsen Institute, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen, Denmark;(2) Statistical Research Unit, Danish Medical and Social Science Research Councils, Denmark;(3) Danish Cancer Registry, Institute of Cancer Epidemiology, under the Danish Cancer Society, Blegdamsvej 9, DK-2100 Copenhagen, Denmark |
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Abstract: | Summary Therapeutic and clinico-pathological data of 1,469 patients with clinical stage I malignant melanoma of the skin without histological evidence of fibrotic areas of regression were examined by multivariate regression analysis. In accordance with a previous analysis anatomical site of tumour, tumour thickness, level of invasion, mitotic rate, ulceration, lymphhocytic reaction, dominant type of invasive tumour cell, and sex were found to act as independent risk factors. The present analysis, furthermore, showed that size of resection margin, diagnostic biopsy, removal of the deep fascia, age at surgery, as well as presence and depth of nevus cells did not influence prognosis when adjusting for the independent risk factors. |
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Keywords: | Malignant melanoma Cutaneous Prognosis Treatment Multivariate regression analysis |
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