Physical training preserves bone mineral density in postmenopausal women with forearm fractures and low bone mineral density |
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Authors: | I Bergström BM Landgren J Brinck B Freyschuss |
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Institution: | (1) Center for Metabolism and Endocrinology, Karolinska Institutet at Karolinska University, Karolinska University Hospital Huddinge, Stockholm, Sweden;(2) Department of Obstetrics and Gynecology, Karolinska Institutet at Karolinska University, Karolinska University Hospital Huddinge, Stockholm, Sweden;(3) Karolinska University Hospital Hudding, 14186 Stockholm, Sweden |
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Abstract: | Summary One hundred and twelve postmenopausal women with low bone mineral density (BMD) and forearm fractures were randomized to physical
training or control group. After one year the total hip BMD was significantly higher in the women in the physical training
group. The results indicate a positive effect of physical training on BMD in postmenopausal women with low BMD.
Introduction The fivefold increase in hip fracture incidence since 1950 in Sweden may partially be due to an increasingly sedentary lifestyle.
Our hypothesis was that physical training can prevent bone loss in postmenopausal women.
Methods One hundred and twelve postmenopausal women 45 to 65 years with forearm fractures and T-scores from −1.0 to −3.0 were randomized
to either a physical training or control group. Training included three fast 30-minute walks and two sessions of one-hour
training per week. Bone mineral density (BMD) was measured in the hip and the lumbar spine at baseline and after one year.
Results A per protocol analysis was performed, including 48 subjects in the training group and 44 subjects in the control group. The
total hip BMD increased in the training group +0.005 g/cm2 (±0.018), +0.58%, while it decreased −0.003 g/cm2 (±0.019), −0.36%,
(p = 0.041) in the control group. No significant effects of physical training were seen in the lumbar spine. A sensitivity intention
to treat analysis, including all randomized subjects, showed no significant effect of physical training on BMD at any site.
Conclusions The results indicate a small but positive effect of physical exercise on hip BMD in postmenopausal women with low BMD. |
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Keywords: | Bone mineral density Forearm fracture Physical training Postmenopausal women |
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