TMC-69, a new antitumor antibiotic with Cdc25A inhibitory activity, produced by Chrysosporium sp. TC1068. Taxonomy, fermentation and biological activities |
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| Authors: | Hirano N Kohno J Tsunoda S Nishio M Kishi N Okuda T Kawano K Komatsubara S Nakanishi N |
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| Institution: | Discovery Research Laboratory, Tanabe Seiyaku Co, Ltd, Saitama, Japan. hiranon@tanabe.co.jp |
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| Abstract: | A new antibiotic designated TMC-69 has been isolated from the fermentation broth of a fungal strain Chrysosporium sp. TC 1068. TMC-69 exhibited moderate in vitro cytotoxic activity. TMC-69-6H, a derivative of TMC-69 prepared by hydrogenation, possessed more potent in vitro cytotoxicity than TMC-69, and exhibited in vivo antitumor activity against murine P388 leukemia and B16 melanoma. TMC-69-6H was found to specifically inhibit Cdc25A and B phosphatases. |
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