| 卵巢上皮性癌患者血清中HER-2/neu自身抗体的表达及诊断价值 |
| |
| 引用本文： | 惠宁,吴冬,王猛,惠宁.卵巢上皮性癌患者血清中HER-2/neu自身抗体的表达及诊断价值[J].第二军医大学学报,2010,31(10):1076-1080. |
| |
| 作者姓名： | 惠宁 吴冬 王猛 惠宁 |
| |
| 作者单位： | 第二军医大学长海医院妇产科,上海,200433 |
| |
| 基金项目： | 全军医学科研“十一五”计划基金(06MB215)~~ |
| |
| 摘 要： | 目的测定卵巢上皮性癌患者血清中HER-2/neu自身抗体的表达水平,探讨其作为卵巢上皮性癌血清学标志物的诊断价值。方法采用ELISA法检测2007年至2009年40例卵巢上皮性癌患者、20例良性上皮性卵巢肿瘤患者和20例正常对照女性的血清HER-2/neu自身抗体水平;采用统计学方法分析血清HER-2/neu自身抗体的诊断价值。结果卵巢上皮性癌患者血清HER-2/neu自身抗体水平显著高于良性上皮性卵巢肿瘤患者和正常女性(P<0.05)。ROC曲线分析显示HER-2/neu自身抗体用于卵巢上皮性癌诊断的灵敏度和特异性分别为47.5%和97.5%;联合CA125检测可提高诊断特异性至90%且不降低灵敏度。偏相关系数表明血清CA125与HER-2/neu自身抗体水平无相关性。结论血清HER-2/neu自身抗体水平与卵巢上皮性癌相关,有望成为卵巢上皮性癌诊断的一种新血清学标志物。
|
| 关 键 词： | 卵巢上皮性癌 HER-2/neu 自身抗体 CA125 |
| 收稿时间： | 4/8/2010 12:00:00 AM |
| 修稿时间： | 2010/8/27 0:00:00 |
Serum HER-2/neu autoantibody in patients with epithelial ovarian cancer and its diagnostic value |
| |
| Hui Ning and WU Dong,WANG Meng,HUI Ning.Serum HER-2/neu autoantibody in patients with epithelial ovarian cancer and its diagnostic value[J].Academic Journal of Second Military Medical University,2010,31(10):1076-1080. |
| |
| Authors: | Hui Ning and WU Dong WANG Meng HUI Ning |
| |
| Institution: | WU Dong,WANG Meng,HUI Ning Department of Obstetrics , Gynecology,Changhai Hospital,Second Military Medical University,Shanghai 200433,China |
| |
| Abstract: | Objective To determine the serum HER-2/neu autoantibody level in patients with epithelial ovarian cancer and to evaluate the potential of using HER-2/neuautoantibody as a tumor marker.Methods The serum HER-2/neu autoantibody levels were measured by ELISA in 20normal controls,20patients with benign epithelial ovarian tumors and 40patients with epithelial ovarian cancer during 2007to 2009.Statistical analysis was performed to determine the diagnostic value of serum HER-2/neu autoantibody. Results The sera of ... |
| |
| Keywords: | epithelial ovarian cancer HER-2/neu autoantibody CA125 |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《第二军医大学学报》浏览原始摘要信息 |
| 点击此处可从《第二军医大学学报》下载免费的PDF全文 |
