银杏叶提取物注射液联合坎地沙坦治疗慢性充血性心力衰竭的疗效观察

目的探讨银杏叶提取物注射液联合坎地沙坦治疗慢性充血性心力衰竭的临床疗效。方法选取2014年2月—2017年2月在商洛市中心医院就诊的慢性充血性心力衰竭患者98例,随机分为对照组和治疗组,每组各49例。对照组口服坎地沙坦酯片,2片/次,1次/d。治疗组在对照组的基础上静脉滴注银杏叶提取物注射液,20 m L加入5%葡萄糖注射液100 m L,糖尿病患者使用生理盐水100 m L,1次/d。两组患者均治疗4周。评价两组患者临床疗效,同时比较治疗前后两组患者超声心电图指标和6 min步行距离变化。结果治疗后,对照组和治疗组的临床总有效率分别为75.51%、93.88%,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者心电图指标每搏输出量(SV)、左室射血分数(LVEF)、每分钟心脏输出量(CO)和心脏指数(CI)均显著升高,左室舒张末内径(LVEDD)显著降低,同组比较差异具有统计学意义(P0.05);且治疗组超声心电图指标较对照组改善更明显,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者6 min步行距离均明显增加(P0.05);且治疗组患者6 min步行距离明显大于对照组(P0.05)。结论银杏叶提取物注射液联合坎地沙坦能逆转慢性充血性心力衰竭患者心脏重塑,改善运动功能,安全性高,具有一定的临床推广应用价值。

Clinical observation of Extract of Ginkgo biloba Leaves Injection combined with candesartan in treatment of chronic congestive heart failure

Objection To explorer the therapeutic effect of Extract of Ginkgo biloba Leaves Injection combined with candesartan in treatment of chronic congestive heart failure. Methods Patients (98 cases) with chronic congestive heart failure in Shangluo Central Hospital from February 2014 to February 2017 were randomly divided into control and treatment groups, and each group had 49 cases. Patients in the control group were po administered with Candesartan Cilexetil Tablets, 2 tablets/time, once daily. Patients in the treatment group were iv administered with Extract of Ginkgo biloba Leaves Injection on the basis of the control group, 20 mL added into 5% glucose injection 100 mL, and diabetics used normal saline 100 mL instead, once daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the change of ultrasonic cardiogram indexes and 6 min walking distance in two groups before and after treatment was compared. Results After treatment, the clinical efficacy in the control and treatment groups were 75.51% and 93.88%, respectively, and there were differences between two groups (P<0.05). After treatment, the ultrasonic cardiogram indexes of SV, LVEF, CO and CI in two groups were significantly increased, but LVEDD was significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the improvement of ultrasonic cardiogram indexes in the treatment group was more obviously than that in the control group, with significant difference between two groups (P<0.05). After treatment, the 6 min walking distance in two groups was significantly increased (P<0.05). And the 6 min walking distance in the treatment group was significantly longer than that in the control group (P<0.05). Conclusion Extract of Ginkgo biloba Leaves Injection combined with candesartan can reverse cardiac remodeling in treatment of chronic congestive heart failure, and improve motor function with high safety, which has a certain clinical application value.