2014—2016年西安市中心医院中药注射剂使用情况分析

目的 分析西安市中心医院2014—2016年中药注射剂的使用情况,为临床合理用药提供参考.方法 调取2014—2016年西安市中心医院中药注射剂的用药数据,对品种、销售金额、用药频率(DDDs)、日均费用(DDC)等进行统计、排序和分析;对2014—2016年由中药注射剂引发的不良反应病例报告进行整理、分析;并利用PASS系统评价中药注射剂的用药合理性.结果 2014—2016年中药注射剂用药金额的构成比分别为9.35%、9.02%、8.80%;活血化瘀类中药注射剂的使用金额和DDDs稳居前列,其不良反应发生率也较高;抗肿瘤类中药注射剂的DDC偏高;中药注射剂引发的不良反应主要表现为皮疹、瘙痒、发热、静脉炎等;中药注射剂使用中存在无适应症用药、用法用量不适宜、溶媒不适宜、联合用药不当、疗程过长等情况.结论 西安市中心医院中药注射剂使用基本合理,但仍存在不合理用药情况,临床药师应加强对不合理用药的干预,减少不良反应的发生,促进临床合理用药.

Analysis on utilization of traditional Chinese medicine injection in Xi'an Central Hospital from 2014 to 2016

Objective To analyze the utilization of traditional Chinese medicine injection in Xi''an Central Hospital from 2014 to 2016, and to provide reference for clinical rational drug use. Methods The drug utilization data of traditional Chinese medicine injections in Xi''an Central Hospital from 2014 to 2016 were collected, and varieties, consumption sum, frequency of drug use (DDDs), and defined daily cost (DDC) were statistically ranked and analyzed. The reports of adverse drug reactions caused by the use of traditional Chinese medicine injections from 2014 to 2016 were collected and analyzed. The PASS clinical pharmacy management system was used to evaluate the rationality of drug use of traditional Chinese medicine injections. Results The constituent ratio of traditional Chinese medicine injections accounted for 9.35%, 9.02% and 8.80% respectively from 2014 to 2016. Consumption sum and DDDs of the Chinese patent injections to promote blood circulation and remove blood stasis were in the forefront, and the incidence of adverse reactions was also higher. DDC of anti-tumor traditional Chinese medicine injection was on the high side. The main adverse reactions caused by traditional Chinese medicine injections were rash, itching, fever, phlebitis, and so on. During the use of Chinese patent injections, problems like inappropriate indications, inappropriate solvent, inappropriate usage and dosage, inappropriate combination of drug use, as well as prolonged therapy, could still be found. Conclusion The utilization of the traditional Chinese medicine injections in Xi''an Central Hospital is basically rational. However, some problems still exist, and it is important for clinical pharmacists to intensify intervention of non-rational drug use in order to decrease the occurrence of ADR, and co-guarantee rational drug use in clinic.