芪参益气滴丸联合养心氏片治疗慢性心力衰竭的疗效观察

目的探讨芪参益气滴丸联合养心氏片治疗慢性心力衰竭的临床疗效。方法选取2015年3月—2016年3月在凤翔县医院治疗的慢性心力衰竭患者100例为研究对象,所有患者随机分为对照组和治疗组,每组各50例。对照组餐后30 min口服养心氏片,3片/次,3次/d。治疗组在对照组基础上口服芪参益气滴丸,0.5 g/次,3次/d。两组患者均治疗60 d。观察两组的临床疗效,比较两组的心功能指标和6 min步行距离。结果治疗后,对照组和治疗组的总有效率分别为74.0%、92.0%,两组比较差异有统计学意义(P0.05)。治疗后,两组左室射血分数(LVEF)、6 min步行距离均显著增加,而左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)均显著降低,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P0.05)。结论芪参益气滴丸联合养心氏片治疗慢性心力衰竭具有较好的临床疗效,可改善心功能,提高运动耐量,安全性较好,具有一定的临床推广应用价值。

Clinical observation of Qishen Yiqi Dropping Pills combined with Yangxinshi Tablets in treatment of chronic heart failure

Objective To explore the clinical effect of Qishen Yiqi Dropping Pills combined with Yangxinshi Tablets in treatment of chronic heart failure. Methods Patients (100 cases) with chronic heart failure in Fengxiang County Hospital from March 2015 to March 2016 were randomly divided into control and treatment groups, and each group had 50 cases. Patients in the control group were po administered with Yangxinshi Tablets 30 min after dinner, 3 tablets/time, three times daily. Patients in the treatment group were po administered with Qishen Yiqi Dropping Pills on the basis of the control group, 0.3 g/time, three times daily. Patients in two groups were treated for 60 d. After treatment, the clinical efficacies were evaluated, and heart function indexes and 6 min walking distance in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 74.0% and 92.0%, respectively, and there was difference between two groups (P<0.05). After treatment, LVEF and 6 min walking distance were significantly increased, but LVEDD and LVESD in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). Conclusion Qishen Yiqi Dropping Pills combined with Yangxinshi Tablets has clinical curative effect in treatment of chronic heart failure, can improve heart function, and enhance exercise tolerance, with good safety, which has a certain clinical application value.