杏丁注射液联合还原型谷胱甘肽治疗慢性肾衰竭的疗效观察

目的探讨杏丁注射液联合还原型谷胱甘肽治疗慢性肾衰竭患者的临床效果。方法选取2016年1月—2016年12月在首都医科大学附属北京潞河医院接受治疗的慢性肾衰竭患者98例,随机分为对照组和治疗组,每组各49例。对照组静脉注射注射用还原型谷胱甘肽,1.8 g/次,1次/d。治疗组患者在对照组的基础上静脉注射杏丁注射液,20 m L溶于生理盐水250 m L,1次/d。两组患者均治疗4周。评价两组患者临床疗效,同时比较治疗前后两组患者临床症状改善情况以及尿蛋白、血清肌酐(SCr)、尿素氮(BUN)和肌酐清除率(Ccr)。结果治疗后,对照组和治疗组总有效率分别为83.67%、95.92%,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者恶心、呕吐、四肢无力和食欲不振等临床症状均明显好转,同组比较差异具有统计学意义(P0.05);且治疗组患者临床症状改善情况显著优于对照组患者,两组比较差异具有统计学意义(P0.05)。治疗后,两组患者尿蛋白、Scr和BUN均显著降低,Ccr显著升高,同组比较差异具有统计学意义(P0.05);且治疗组患者尿蛋白、Scr、BUN和Ccr含量明显优于对照组患者,两组患者比较差异具有统计学意义(P0.05)。结论杏丁注射液联合还原型谷胱甘肽治疗慢性肾衰竭患者应用能够有效改善患者生化指标和临床症状,具有一定的临床推广应用价值。

Clinical observation of Xingding Injection combined with reduced glutathione in treatment of chronic renal failure

Objective To explore the clinical effect of Xingding Injection combined with reduced glutathione in treatment of chronic renal failure. Methods Patients (98 cases) with chronic renal failure in Beijing Luhe Hospital of Capital Medical University from January 2016 to December 2016 were randomly divided into control and treatment groups, and each group had 49 cases. Patients in the control group were iv administered with Reduced Glutathione for injection, 1.8 g/time, once daily. Patients in the treatment group were iv administered with Xingding Injection on the basis of the control group, 20 mL added into normal saline 250 mL, once daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the improvement of clinical symptoms, urine protein, Scr, BUN and Ccr in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 83.67% and 95.92%, respectively, and there were differences between two groups (P<0.05). After treatment, the nausea, vomiting, myasthenia of limbs and anorexia in two groups was obviously improved, and the difference was statistically significant in the same group (P<0.05). And the improvement of clinical symptoms in the treatment group was obviously better higher than that the control group, with significant difference between two groups (P<0.05). After treatment, the urine protein, Scr and BUN in two groups was significantly decreased, but Ccr was significantly increased, and there were differences in the same group (P<0.05). And these indexes in the treatment group were obviously better than those the control group, with significant difference between two groups (P<0.05). Conclusion Xingding Injection combined with reduced glutathione can effectively improve the biochemical indicators and clinical symptoms in treatment of chronic renal failure, which has a certain clinical application value.