硫酸沙丁胺醇联合氨茶碱治疗小儿哮喘的疗效观察

目的观察硫酸沙丁胺醇联合氨茶碱治疗小儿哮喘的临床疗效。方法选取2015年1月—2016年1月神木市医院收治的小儿哮喘患者79例,随机分成对照组(39例)和治疗组(40例)。对照组患儿静脉注射氨茶碱注射液,4 mg/kg加入10%葡萄糖注射液,2次/d;治疗组患儿在对照组的基础上口腔吸入硫酸沙丁胺醇吸入气雾剂,1揿/次,2次/d。两组患儿均规律治疗1周。评价两组患者临床疗效,同时比较治疗前后两组患儿临床症状消失时间和不良反应情况。结果治疗后,对照组总有效率为74.36%,显著低于治疗组的92.50%,两组比较差异具有统计学意义(P0.05)。治疗后,两组患儿咳嗽、哮鸣音以及呼吸困难等临床症状完全消失时间以及不良反应发生情况相当,两组比较差异无统计学意义。结论硫酸沙丁胺醇联合氨茶碱治疗小儿哮喘的临床优势明显,安全性可靠。

Clinical observation of salbutamol sulfate combined with aminophylline in treatment of children with asthma

Objective To observe the clinical efficacy of salbutamol sulfate combined with aminophylline in treatment of children with asthma. Methods Children (79 cases) with asthma in Shenmu County Hospital from January 2015 to January 2016 were randomly divided into control (39 cases) and treatment (40 cases) groups. Children in the control group were iv administered with Aminophylline Injection, 4 mg/kg added into 10% glucose injection, twice daily. Children in the treatment group were administered with Salbutamol Sulphate Inhalation Aerosol by oral inhalation on the basis of the control group, 1 press/time, twice daily. Children in two groups were treated for 1 week. After treatment, the clinical efficacy was evaluated, and the clinical symptom disappearance time and adverse reactions in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 74.36%, which was significantly lower than 92.50% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the differences of the disappearance time of coughing, wheezing, and breathing difficulties, and adverse reactions in two groups had no statistical significance. Conclusion Salbutamol sulfate combined with aminophylline has obvious clinical advantages in treatment of children with asthma with high safety.