赖氨葡锌颗粒联合消旋卡多曲治疗小儿轮状病毒性肠炎的临床研究

目的探讨赖氨葡锌颗粒联合消旋卡多曲治疗小儿轮状病毒性肠炎的临床疗效。方法选取2014年3月—2016年3月在宝鸡市妇幼保健院进行治疗的轮状病毒性肠炎患儿108例,依据治疗方案的差别分为对照组(54例)和治疗组(54例)。对照组口服消旋卡多曲颗粒,30 g/次,3次/d。治疗组在对照组的基础上口服赖氨葡锌颗粒,5 g/次,2次/d。两组患儿均治疗7 d。评价两组患者临床疗效,同时比较治疗前后两组患儿临床症状消失时间和心肌酶指标变化。结果治疗后,对照组总有效率为85.19%,显著低于治疗组的97.53%;两组比较差异具有统计学意义(P0.05)。治疗后,治疗组患儿发热、腹泻、呕吐消失时间均显著短于对照组患儿,两组比较差异具有统计学意义(P0.05)。治疗后,两组血清磷酸肌酸激酶(CK)、磷酸肌酸激酶同功酶(CK-MB)和乳酸脱氢酶(LDH)水平均显著降低,同组比较差异具有统计学意义(P0.05);且治疗组患儿心肌酶指标比对照组降低更显著,两组比较差异具有统计学意义(P0.05)。结论赖氨葡锌颗粒联合消旋卡多曲治疗小儿轮状病毒性肠炎可有效改善患儿临床症状,缓解心肌损害,具有一定的临床推广应用价值。

Clinical study on Compound Lysine Hydrochloride and Zinc Gluconate Granules combined with racecadotril in treatment of infantile rotavirus enteritis

Objective To investigate the clinical efficacy of Compound Lysine Hydrochloride and Zinc Gluconate Granules combined with racecadotril in treatment of infantile rotavirus enteritis. Methods Children (108 cases) with rotavirus enteritis in Maternal and Child Health Hospital of Baoji from March 2014 to March 2016 were divided into control (54 cases) and treatment (54 cases) groups based on different treatment. Children in the control group were po administered with Racecadotril Granules, 30 mg/time, three times daily. Children in the treatment group were po administered with Compound Lysine Hydrochloride and Zinc Gluconate Granules on the basis of the control group, 5 g/time, twice daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the change of clinical symptom disappearance time and myocardial enzymes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 85.19%, which was significantly lower than 97.53% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the disappearance time of fever, diarrhea, and vomiting in treatment group was significantly shorter than that in the control group, with significant difference between two groups (P<0.05). After treatment, the CK, CK-MB, and LDH levels in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the myocardial enzyme indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Compound Lysine Hydrochloride and Zinc Gluconate Granules combined with racecadotril can effectively improve the clinical symptoms in treatment of infantile rotavirus enteritis, and relieve myocardial damage, which has a certain clinical application value.