感咳双清胶囊联合沙丁胺醇治疗小儿毛细支气管炎的疗效观察

目的观察感咳双清胶囊联合沙丁胺醇治疗小儿毛细气管炎的临床疗效。方法收集2011年3月—2015年3月在枣庄市妇幼保健院就诊的毛细支气管炎患儿109例,随机分为对照组(54例)和治疗组(55例)。对照组患儿雾化吸入硫酸沙丁胺醇吸入气雾剂,0.01~0.03 mg/kg加入生理盐水2 m L。治疗组患儿在对照组的基础上口服感咳双清胶囊,2粒/次,3次/d。两组患儿均连续治疗7 d。评价两组患者临床疗效,同时比较治疗前后两组患儿临床症状消失时间、咳嗽积分和肺功能指标情况。结果治疗后,对照组的临床总有效率为81.48%,显著低于治疗组的94.55%,两组比较差异具有统计学意义(P0.05)。治疗后,两组患儿日间和夜间咳嗽评分均明显降低,同组比较差异具有统计学意义(P0.05);且治疗后治疗组喘憋、咳嗽、哮鸣音和湿啰音消失时间及咳嗽积分均明显好于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,治疗组患儿呼吸频率(RR)、潮气量(VT)、功能残气量(FRC)、达峰容积比(VPEF/VE)和达峰时间比(t PTEF/t E)均高于对照组患儿,FRC低于对照组,两组比较差异具有统计学意义(P0.05)。结论感咳双清胶囊联合沙丁胺醇治疗儿童毛细支气管炎能缩短症状消失时间,改善呼吸功能,具有一定的临床推广应用价值。

Clinical observation of Ganke Shuangqing Capsules combined with salbutamol in treatment of children with bronchiolitis

Objective To observe the clinical effect of Ganke Shuangqing Capsules combined with salbutamol in treatment of children with bronchiolitis. Methods Children (109 cases) with bronchiolitis in Maternity and Child Health Care of Zaozhuang from March 2011 to March 2015 were randomly divided into control (54 cases) and treatment (55 cases) groups. Children in the control group were aerosol inhalation administered with Salbutamol Sulphate Inhalation Aerosol, 0.01-0.03 mg/kg added into normal saline 2 mL. Children in the treatment group were po administered with Ganke Shuangqing Capsules on the basis of the control group, 2 grains/time, three times daily. Children in two groups were treated for 7 d. After treatment, the clinical efficacy was evaluated, and the disappearance time of clinical symptoms, cough scores, and lung function indexes in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 81.48%, which was significantly lower than 94.55% in the treatment group, and there were differences between two groups (P<0.05). After treatment, the daytime and nighttime cough scores in two groups were significantly decreased, and there were differences in the same group (P<0.05). And the disappearance time of shortness of breath, coughing, wheezing and wet rales, and cough scores in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the RR, VT, FRC, VPEF/VE, and tPTEF/tE levels in the treatment group were obviously higher than those in the control group, and FRC level was obviously lower than that in the control group, with significant difference between two groups (P<0.05). Conclusion Ganke Shuangqing Capsules combined with salbutamol can shorten the symptoms disappearance time and improve respiratory function in treatment of children with bronchiolitis, which has a certain clinical application value.