热淋清胶囊联合阿奇霉素治疗尿路感染的临床研究

目的探讨热淋清胶囊联合阿奇霉素注射液治疗尿路感染的临床疗效。方法选取2016年3月—2017年3月在海南省万宁市人民医院进行治疗的尿路感染患者102例作为研究对象,根据用药的差别将入组患者分为对照组和治疗组,每组各51例。对照组静脉滴注阿奇霉素注射液,0.5 g加入到0.5%葡萄糖注射液500 m L中,1次/d。治疗组在对照组基础上口服热淋清胶囊,1.8 g/次,3次/d。两组均治疗7 d。观察两组的疗效,比较两组的尿液细菌清除率、临床症状评分和血清学指标。结果治疗后,对照组和治疗组的总有效率分别为80.39%、96.08%,两组比较差异有统计学意义(P0.05)。治疗后,对照组和治疗组尿液细菌清除率分别为84.31%、98.04%,两组比较差异具有统计学意义(P0.05)。治疗后,两组尿频、尿急、尿痛的临床症状评分均显著降低,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组血清血红素加氧酶-1(HO-1)、降钙素(PCT)和白细胞介素-6(IL-6)水平均显著降低,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P0.05)。结论热淋清胶囊联合阿奇霉素注射液治疗尿路感染具有较好的临床疗效,可有效清除尿液细菌,改善临床症状和机体炎症反应,具有一定的临床推广应用价值。

Clinical study on Relinqing Capsules combined with azithromycin in treatment of urinary tract infection

Objective To investigate the clinical efficacy of Relinqing Capsules combined with Azithromycin Injection in treatment of urinary tract infection. Methods Patients (102 cases) with urinary tract infection in People''s Hospital of Wanning from March 2016 to March 2017 were enrolled in this study. According to the difference treatment plan, patients were divided into the control and treatment groups, and each group had 51 cases. Patients in the control group were iv administered with Azithromycin Injection, 0.5 g added into 5% glucose solution 500 mL, once daily. Patients in the treatment group were po administered with Relinqing Capsules on the basis of the control group, 1.8 g/time, three times daily. Patients in two groups were treated for 7 d. After treatment, the clinical efficacies were evaluated, and urinary bacterial clearance, clinical symptom scores, and serological indexes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.39% and 96.08%, respectively, and there was difference between two groups (P<0.05). After treatment, the urinary bacterial clearance in the control and treatment groups were 84.31% and 98.04%, respectively, and there was difference between two groups (P<0.05). After treatment, the clinical symptom scores of frequent urination, urgency, and dysuria in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the levels of HO-1, PCT, and IL-6 in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Relinqing Capsules combined with Azithromycin Injection has clinical curative effect in treatment of urinary tract infection, can effectively eliminate urinary bacteria, improve clinical symptoms and inflammatory response, which has a certain clinical application value.