丁苯酞软胶囊治疗脑梗死的临床研究

目的探讨丁苯酞软胶囊治疗脑梗死的临床疗效。方法选取2014年5月—2016年5月新汶矿业集团莱芜中心医院神经内分泌科收治的脑梗死患者97例为研究对象,所有患者随机分为对照组(49例)和治疗组(48例)。对照组在溶栓24 h无出血征象后口服阿司匹林肠溶片,300 mg/次,1次/d。治疗组口服丁苯酞软胶囊,0.2 g/次,3次/d。两组患者均连续治疗2周。观察两组的临床疗效,比较两组的血管内皮功能和血清同型半胱氨酸(Hcy)水平。结果治疗后,对照组和治疗组的总有效率分别为55.1%、77.1%,两组比较差异有统计学意义(P0.05)。治疗后,两组内皮素-1(ET-1)、Hcy水平显著降低,而一氧化氮(NO)、内皮型一氧化氮合酶(e NOS)水平显著升高,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标的改善程度明显优于对照组,两组比较差异具有统计学意义(P0.05)。两组不良反应发生率比较差异无统计学意义。结论丁苯酞软胶囊治疗脑梗死具有较好的临床疗效,能降低患者ET-1和Hcy水平,升高NO、e NOS水平,改善血管内皮功能,缓解神经功能损伤,具有一定临床推广应用价值。

Clinical study on Butylphthalide Soft Capsules in treatment of cerebral infarction

Objective To investigate the clinical effect of Butylphthalide Soft Capsules in treatment of cerebral infarction. Methods Patients (97 cases) with cerebral infarction in Department of Neuroendocrine of Laiwu Center Hospital of Xinwen Mining Industry Group from May 2014 to May 2016 were randomly divided into the control group (49 cases) and the treatment group (48 cases). Patients in the control group were po administered with Aspirin Enteric-coated Tablets after thrombolysis for 24 h without signs of bleeding, 300 mg/time, once daily. Patients in the treatment group were po administered with Butylphthalide Soft Capsules, 0.2 g/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and vascular endothelial function and serum Hcy levels in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 55.1% and 77.1%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of endothelin 1 (ET-1) and homocysteine (Hcy) in two groups were significantly decreased, but the levels of nitric oxide (NO) and endothelial nitric oxide synthase (eNOS) were significantly increased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly better than those in the control group, with significant difference between two groups (P<0.05). There were no significant differences of adverse reaction rates between two groups. Conclusion Butylphthalide Soft Capsules has clinical curative effect in treatment of cerebral infarction, and can decrease the levels of ET-1 and Hcy, increase the levels of NO and eNOS, improve vascular endothelial function, and relieve nerve function damage, which has a certain clinical application value.