复方丹参注射液联合间苯三酚治疗妊娠高血压综合征的临床研究

目的探讨复方丹参注射液联合间苯三酚注射液治疗妊娠高血压综合征的临床疗效。方法选择2015年1月—2016年10月在襄阳市中心医院就诊的妊娠高血压患者120例作为研究对象,将所有患者随机分为对照组和治疗组,每组各60例。对照组静脉滴注间苯三酚注射液,40 mg加入到5%或10%葡萄糖注射溶液250 m L中,1次/d。治疗组在对照组基础上静脉滴注丹参注射液,10 m L加入到10%葡萄糖注射液500 m L中,1次/d。两组患者均连续治疗2周。观察两组的临床疗效,比较两组血清胱抑素C(Cys C)和同型半胱氨酸(Hcy)水平、分娩情况和母婴结局情况。结果治疗后,对照组和治疗组的总有效率分别为76.67%、91.67%,两组比较差异有统计学意义(P0.05)。治疗后,两组Cys C和Hcy水平均显著降低,同组治疗前后比较差异有统计学意义(P0.05);且治疗组这些观察指标明显低于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,治疗组引产比例明显低于对照组,而治疗组自然分娩比例明显高于对照组,两组比较差异有统计学意义(P0.05)。治疗后,治疗组产后出血和新生儿窒息发生率均低于对照组,两组比较差异有统计学意义(P0.05)。结论复方丹参注射液联合间苯三酚注射液治疗妊娠高血压综合征具有较好的临床疗效,可改善分娩情况和母婴结局,调节Cys C和Hcy水平,具有一定的临床推广应用价值。

Clinical study on Compound Salvia Miltiorrhiza Injection combined with phloroglucinol in treatment of pregnancy-induced hypertension syndrome

Objective To evaluate the clinical efficacy of Compound Salvia Miltiorrhiza Injection combined with Phloroglucinol Injection in treatment of pregnancy-induced hypertension syndrome. Methods Patients (120 cases) with pregnancy-induced hypertension syndrome in Xiangyang Central Hospital from January 2015 to October 2016 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were iv administered with Phloroglucinol Injection, 40 mg added into 5% or 10% glucose solution 250 mL, once daily. Patients in the treatment group were iv administered with Compound Salvia Miltiorrhiza Injection on the basis of the control group, 10 mL added into 10% glucose solution 500 mL, once daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and the levels of CysC and Hcy, delivery conditions, maternal and infant outcomes in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 76.67% and 91.67%, respectively, and there was difference between two groups (P<0.05). After treatment, the levels of CysC and Hcy in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P<0.05). After treatment, the proportion of induced abortion in the treatment group was significantly lower than that in the control group, but the proportion of natural childbirth in the treatment group was significantly higher than that in the control group, and there was difference between two groups (P<0.05). After treatment, the incidence of postpartum hemorrhage and neonatal asphyxia in the treatment group were lower than those in the control group, and there was difference between two groups (P<0.05). Conclusion Compound Salvia Miltiorrhiza Injection combined with Phloroglucinol Injection has clinical curative effect in treatment of pregnancy-induced hypertension syndrome, can improve delivery condition and maternal and infant outcome, can regulate the levels of CysC and Hcy, which has a certain clinical application value.