蒲地蓝消炎口服液联合莪术油葡萄糖注射液治疗儿童疱疹性咽峡炎的临床研究

目的探讨蒲地蓝消炎口服液联合莪术油葡萄糖注射液治疗儿童疱疹性咽峡炎的临床疗效。方法选取陕西省人民医院儿童病院2016年5月—2017年5月收治的92例疱疹性咽峡炎患儿为研究对象,随机分为对照组和治疗组,每组各46例。对照组患儿静脉滴注莪术油葡萄糖注射液10 mg/(kg·d),1次/d。治疗组在对照组基础上口服蒲地蓝消炎口服液,10 m L/次,3次/d。两组患儿均连续治疗1周。评价两组患儿临床疗效,同时比较治疗前后两组患儿临床症状和体征消失时间以及血清炎性因子水平。结果治疗后,对照组患者总有效率为86.96%,显著低于治疗组的97.83%,两组比较差异具有统计学意义(P0.05)。治疗后,治疗组临床症状、发热和疱疹消退时间均显著短于对照组,两组比较差异具有统计学意义(P0.05)。治疗后,两组患儿血清白细胞介素-6(IL-6)、IL-10和肿瘤坏死因子-α(TNF-α)水平均显著下降,同组比较差异具有统计学意义(P0.05);且治疗组患儿血清炎性因子水平显著低于对照组,两组比较差异具有统计学意义(P0.05)。结论蒲地蓝消炎口服液联合莪术油葡萄糖注射液治疗儿童疱疹性咽峡炎,可明显缩短临床症状和体征消失时间,降低患儿炎性水平,具有一定的临床推广应用价值。

Clinical study on Pudilan Xiaoyan Oral Liquid combined with Zedoary Turmeric Oil and Glucose Injection in treatment of children herpangina

Objective To study the clinical effect of Pudilan Xiaoyan Oral Liquid combined with Zedoary Turmeric Oil and Glucose Injection in treatment of children herpangina. Methods Children (92 cases) with herpangina in Childrens' Hospital of Shaanxi Provincial People's Hospital from May 2016 to May 2017 were randomly divided into control and treatment groups, and each group had 46 cases. Children in the control group were iv administered with Zedoary Turmeric Oil and Glucose Injection, the dosage was 10 mg/(kg·d),once daily.Children in the treatment group were po administered with Pudilan Xiaoyan Oral Liquid on the basis of the control group, 10 mL/time, three times daily. Children in two groups were treated for 1 week. After treatment, the clinical efficacy was evaluated, and the disappearance time of clinical symptoms and signs, and serum levels of IL-6, IL-10 and TNF-α in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 86.96%, which was significantly lower than 97.83% in the treatment group, and the difference was statistically significant between two groups (P < 0.05). After treatment, the disappearance time of clinical symptoms, fever and herpes in the treatment group was shorter than that in the control group, with significant difference between two groups (P < 0.05). After treatment, the serum IL-6, IL-10 and TNF-α level in two groups was significantly decreased, the difference was statistically significant in the same group (P < 0.05). And the serum inflammatory factor level in the treatment group was significantly lower than that in the control group (P < 0.05). Conclusion Pudilan Xiaoyan Oral Liquid combined with Zedoary Turmeric Oil and Glucose Injection can significantly shorten the disappearance time of clinical symptoms and signs, and reduce the inflammatory level in treatment of children herpangina, which has a certain clinical application value.