茵胆平肝胶囊联合多烯磷脂酰胆碱治疗酒精性肝病的临床研究

目的探索茵胆平肝胶囊联合多烯磷脂酰胆碱治疗酒精性肝病的临床疗效。方法选取2014年2月—2017年4月渭南市中心医院收治的234例酒精性肝病患者,随机分为对照组和治疗组,每组各117例。对照组静脉滴注多烯磷脂酰胆碱注射液,30 m L加入5%葡萄糖注射液250 m L,1次/d。治疗组在对照组治疗基础上口服茵胆平肝胶囊,2粒/次,2次/d。两组均连续治疗30 d。观察两组患者的临床疗效,比较两组治疗前后天冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆红素(TBil)、碱性磷酸酶(ALP)的变化情况。结果治疗后,对照组和治疗组的总有效率分别为80.34%、94.87%,两组比较差异有统计学意义(P0.05)。治疗后,两组AST、ALT、TBil、ALP水平均显著降低,同组治疗前后差异有统计学意义(P0.05);治疗后,治疗组AST、ALT、TBil、ALP水平显著低于对照组,两组比较差异有统计学意义(P0.05)。对照组和治疗组的不良反应发生率分别为28.2%、9.4%,两组比较差异有统计学意义(P0.05)。结论茵胆平肝胶囊联合多烯磷脂酰胆碱治疗酒精性肝病具有显著疗效,能明显改善患者肝功能,不良反应较少,具有一定的临床推广应用价值。

Clinical observation of Yindan Pinggan Capsules combined with polyene phosphatidylcholine in treatment of alcoholic liver disease

Objective To explore the clinical efficacy of Yindan Pinggan Capsules combined with polyene phosphatidylcholine in treatment of alcoholic liver disease. Methods Patients (234 cases) with alcoholic liver disease in Weinan Central Hospital from February 2014 to April 2017 were randomly divided into control (117 cases) and treatment (117 cases) groups. Patients in the control group were iv administered with Polyene Phosphatidylcholine Injection, 30 mL added into 5% glucose injection, once daily. Patients in the treatment group were po administered with Yindan Pinggan Capsules on the basis of the control group, 2 grains/time, twice daily. All patients were continuously treated for 30 d. After treatment, the clinical efficacy was evaluated, and the changes of AST, ALT, TBil, and ALP in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups were 80.34% and 94.87%, respectively, and there was difference between two groups (P<0.05). After treatment, AST, ALT, TBil, and ALP in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, AST, ALT, TBil, and ALP in the treatment group were lower than those in the control group, and there was difference between two groups (P<0.05). After treatment, the incidence of adverse reactions in the control and treatment groups were 28.2% and 9.4%, respectively, and there was difference between two groups (P<0.05). Conclusion Yindan Pinggan Capsules combined with polyene phosphatidylcholine has a significant effect in treatment of alcoholic liver disease, and can obviously improve the liver function of the patient with less adverse reaction, which has a certain clinical application value.