| 山苦瓜中三萜及甾体成分的研究 |
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| 引用本文： | 罗蕾,李祖强,张元清,黄荣.山苦瓜中三萜及甾体成分的研究[J].药学学报,1998,33(11):839-842. |
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| 作者姓名： | 罗蕾 李祖强 张元清 黄荣 |
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| 作者单位： | 云南大学实验中心，云南教育学院化学系 |
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| 基金项目： | 国家自然科学基金,云南省应用科学基金 |
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| 摘 要： | 从葫芦科植物山苦瓜(Momordica dioica)干燥块根中分离鉴定出5个三萜及甾体化合物:α-菠甾醇硬脂酸酯(I),α-菠甾醇 3-O-β-D-吡喃葡萄糖甙(II),3β-羟基-23-氧-齐墩果-12-烯-28-酸-3-O-β-D-吡喃葡萄糖醛酸甙(II),3β-羟基-23-氧-齐墩果-12-烯-28-酸-3-O-β-D-吡喃葡萄糖甙(IV)和3β,23-二羟基齐墩果-12-烯-28-酸-3-O-β-D-吡喃葡萄糖甙(V)。其中,成分II为一新化合物。
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| 关 键 词： | 山苦瓜 五环三萜 菠甾醇 |
| 收稿时间： | 1997-12-11 |
TRITERPENES AND STEROIDAL COMPOUNDS FROM MOMORDICA DIOICA |
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| Luo Lei,Li Zuqiang,Zhang Yuanqing and Huang Rong.TRITERPENES AND STEROIDAL COMPOUNDS FROM MOMORDICA DIOICA[J].Acta Pharmaceutica Sinica,1998,33(11):839-842. |
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| Authors: | Luo Lei Li Zuqiang Zhang Yuanqing and Huang Rong |
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| Institution: | Department of Chemistry, Yunnan Education College, Kunming 650031. |
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| Abstract: | Three triterpenes and two steroidal compounds were isolated from the dry root of Momordica dioica. Their structures were elucidated by spectral analyses (MS, IR, 1HNMR, 13CNMR and DEPT) and chemical methods. These compounds are alpha-spinasterol octadecanonate(I), alpha-spinasterol-3-O-beta-D-glucopyranoside(II), 3-O-beta-D-glucuronopyranosyl gypsogenin(III), 3-O-beta-D-glucopyranosyl gypsogenin(IV) and 3-O-beta-D-glucopyranosyl hederagenin(V). Constituent III is a new compound. The CHCl3 extract of Momordica dioica roots and five isolated constituents showed anticancer activity in pharmacologic testing on cancer cell(L1210). The growth inhibitory index(%) of compound II was shown to be 50%, at the dose of 4 micrograms.ml-1. |
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| Keywords: | Momordica dioica Pentacyclic triterpenes Spinasterol |
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