| 海南粗榧新碱衍生物HH07A在大鼠体内的代谢转化研究 |
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| 引用本文： | 张文江,周同惠.海南粗榧新碱衍生物HH07A在大鼠体内的代谢转化研究[J].药学学报,1998,33(3):212-216. |
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| 作者姓名： | 张文江 周同惠 |
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| 作者单位： | 中国医学科学院中国协和医科大学药物研究所 |
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| 摘 要： | 用GC-MS联用技术对海南粗榧新碱衍生物HH07A在大鼠体内代谢转化进行了研究。尿样经XAD-2固相提取、酶水解、浓缩并硅烷化,用GC-MS联用仪分离鉴定尿中HH07A及其4个代谢物,推断4个代谢物结构及其体内代谢途经。
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| 关 键 词： | 海南粗榧 体内代谢 气质联用 |
| 收稿时间： | 1997-01-28 |
Studies on urinary metabolites of HH07A, a derivative of hainanensine, in rats] |
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| Zhang Wenjiang and Zhou Tonghui.Studies on urinary metabolites of HH07A, a derivative of hainanensine, in rats][J].Acta Pharmaceutica Sinica,1998,33(3):212-216. |
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| Authors: | Zhang Wenjiang and Zhou Tonghui |
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| Institution: | Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050. |
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| Abstract: | The metabolism of HH07A in the rat has been investigated by GC-MS. After oral administration of HH07A, the rat urine was passed through a macroporous XAD-2 resin column and eluted with methanol. The methanol extract was hydrolyzed with glucuronidase, extracted with dichloromethane and concentrated for TMS derivatization with GC-MS. The mass spectra of HH07A and its four metabolites as well as their derivatives were presented. The structures of the metabolites were proposed and the in vivo metabolic pathway of HH07A was given in Figure 6. |
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| Keywords: | GC-MS Metabolites Cephalotaxus hainanensis |
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