| 杂环化合物取代的5-氟尿嘧啶衍生物的合成及抗肿瘤活性 |
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| 引用本文： | 毛曼君,陈耀祖,田瑄. 杂环化合物取代的5-氟尿嘧啶衍生物的合成及抗肿瘤活性[J]. 药学学报, 1998, 33(5): 389-391 |
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| 作者姓名： | 毛曼君 陈耀祖 田瑄 |
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| 作者单位： | 1. 中科院兰州地质所
2. 兰州大学化学系,兰州,730000 |
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| 摘 要： | 杂环化合物取代的５氟尿嘧啶衍生物的合成及抗肿瘤活性毛曼君陈耀祖田（中科院兰州地质所；兰州大学化学系，兰州７３００００）杂环化合物大都有广泛的生物活性，据文献［１，２］报道，有巯基的嘧啶环系列化合物有抗癌活性和免疫增强作用。因而，设想给５氟尿...
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| 关 键 词： | 5-氟尿嘧啶 杂环化合物 抗肿瘤活性 |
| 收稿时间： | 1997-01-28 |
SYNTHESIS AND ANTITUMOR ACTIVITY OF NEW HETEROCYCLIC 5-FLUOROURACIL DERIVATIVES |
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| Mao Manjun,Chen Yaozu,Tian Xuan. SYNTHESIS AND ANTITUMOR ACTIVITY OF NEW HETEROCYCLIC 5-FLUOROURACIL DERIVATIVES[J]. Acta pharmaceutica Sinica, 1998, 33(5): 389-391 |
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| Authors: | Mao Manjun Chen Yaozu Tian Xuan |
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| Affiliation: | Lanzhou Institute of Geology, Chinese Academy of Sciences. |
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| Abstract: | Two new compounds I and II of 5-FU derivatives have been synthesized. The structures of the new compounds were confirmed by 1HNMR, MS, IR, UV and elemental analysis. The antitumor activities of compound I was tested against KB, HCT-8 and A2780. The preliminary results showed that the activity of compound I was stronger than that of HCFU and 5-FU. |
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| Keywords: | Heterocyclic compound Antitumor activity 5-Fluorouracil |
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