| 乙酰丹酚酸A对血小板花生四烯酸代谢的影响 |
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| 引用本文： | 吁文贵,徐理纳. 乙酰丹酚酸A对血小板花生四烯酸代谢的影响[J]. 药学学报, 1998, 33(1): 62-63 |
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| 作者姓名： | 吁文贵 徐理纳 |
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| 作者单位： | 中国医学科学院、中国协和医科大学药物研究所,北京,100050 |
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| 摘 要： | 乙酰丹酚酸Ａ对血小板花生四烯酸代谢的影响吁文贵徐理纳（中国医学科学院、中国协和医科大学药物研究所，北京１０００５０）乙酰丹酚酸Ａ（ａｃｅｔｙｌｓａｌｖｉａｎｏｌｉｃａｃｉｄＡ，ＡＳＡＡ）在体内外能明显抑制花生四烯酸（ａｒａｃｈｉｄｏｎｉｃａｃｉｄ，Ａ...
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| 关 键 词： | 丹参 丹酚酸 花生四烯酸 血栓素A_2 乙酰丹酚酸A |
| 收稿时间： | 1996-08-05 |
EFFECTS OF ACETYLSALVIANOLIC ACID A ON ARACHIDONIC ACID METABOLISM IN PLATELETS |
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| Yu Wengui,Xu Lina. EFFECTS OF ACETYLSALVIANOLIC ACID A ON ARACHIDONIC ACID METABOLISM IN PLATELETS[J]. Acta pharmaceutica Sinica, 1998, 33(1): 62-63 |
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| Authors: | Yu Wengui Xu Lina |
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| Affiliation: | Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050. |
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| Abstract: | Acetylsalvianolic acid A (ASAA) has been shown to be an antiplatelet compound. Our studies with RIA showed that: at the dosage of inhibiting platelet aggregation, ASAA was found to inhibit the formation of cyclooxygenase pathway metabolites TXB2 in platelets. In addition, ASAA was also shown to promote the formation of 6-keto-PGF1 alpha in rabbit aortic rings in vitro. The above results suggest that ASAA may inhibit the proaggregator TXA2 formation, promote mildly the antiaggregator PGI2 generation and probably, whereby, exert its antiplatelet activity. |
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| Keywords: | Salvianolic acid Arachidonic acid Thrombaxane A2 Acetylsalvianolic acid A Salvia miltiorrhiza |
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